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Gartner, Anton
DNA Damage Response and Genetic Toxicology
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Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing

Author(s)
Jantsch, VerenaTang, LoisPasierbek, PawelPenkner, AlexandraNayak, SudhirBaudrimont, AntoineSchedl, TimGartner, AntonLoidl, Josef
Issued Date
2007-12
DOI
10.1091/mbc.E07-03-0243
URI
https://scholarworks.unist.ac.kr/handle/201301/31010
Fulltext
https://www.molbiolcell.org/doi/10.1091/mbc.e07-03-0243
Citation
MOLECULAR BIOLOGY OF THE CELL, v.18, no.12, pp.4911 - 4920
Abstract
A novel gene, prom-1, was isolated in a screen for Caenorhabditis elegans mutants with increased apoptosis in the germline. prom-1 encodes an F-box protein with limited homology to the putative human tumor suppressor FBXO47. Mutations in the prom-1 locus cause a strong reduction in bivalent formation, which results in increased embryonic lethality and a Him phenotype. Furthermore, retarded and asynchronous nuclear reorganization as well as reduced homologous synapsis occur during meiotic prophase. Accumulation of recombination protein RAD-51 in meiotic nuclei suggests disturbed repair of double-stranded DNA breaks. Nuclei in prom-1 mutant gonads timely complete mitotic proliferation and premeiotic replication, but they undergo prolonged delay upon meiotic entry. We, therefore, propose that prom-1 regulates the timely progression through meiotic prophase I and that in its absence the recognition of homologous chromosomes is strongly impaired.
Publisher
AMER SOC CELL BIOLOGY
ISSN
1059-1524
Keyword
SYNAPTONEMAL COMPLEXNUCLEAR REORGANIZATIONCHIASMA FORMATIONCROSSING-OVERGENE FAMILYSYNAPSISRECOMBINATIONCAENORHABDITIS-ELEGANS GERMLINEDAMAGE-INDUCED APOPTOSISC-ELEGANS

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