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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 4920 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 4911 | - |
dc.citation.title | MOLECULAR BIOLOGY OF THE CELL | - |
dc.citation.volume | 18 | - |
dc.contributor.author | Jantsch, Verena | - |
dc.contributor.author | Tang, Lois | - |
dc.contributor.author | Pasierbek, Pawel | - |
dc.contributor.author | Penkner, Alexandra | - |
dc.contributor.author | Nayak, Sudhir | - |
dc.contributor.author | Baudrimont, Antoine | - |
dc.contributor.author | Schedl, Tim | - |
dc.contributor.author | Gartner, Anton | - |
dc.contributor.author | Loidl, Josef | - |
dc.date.accessioned | 2023-12-22T09:07:14Z | - |
dc.date.available | 2023-12-22T09:07:14Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2007-12 | - |
dc.description.abstract | A novel gene, prom-1, was isolated in a screen for Caenorhabditis elegans mutants with increased apoptosis in the germline. prom-1 encodes an F-box protein with limited homology to the putative human tumor suppressor FBXO47. Mutations in the prom-1 locus cause a strong reduction in bivalent formation, which results in increased embryonic lethality and a Him phenotype. Furthermore, retarded and asynchronous nuclear reorganization as well as reduced homologous synapsis occur during meiotic prophase. Accumulation of recombination protein RAD-51 in meiotic nuclei suggests disturbed repair of double-stranded DNA breaks. Nuclei in prom-1 mutant gonads timely complete mitotic proliferation and premeiotic replication, but they undergo prolonged delay upon meiotic entry. We, therefore, propose that prom-1 regulates the timely progression through meiotic prophase I and that in its absence the recognition of homologous chromosomes is strongly impaired. | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY OF THE CELL, v.18, no.12, pp.4911 - 4920 | - |
dc.identifier.doi | 10.1091/mbc.E07-03-0243 | - |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.scopusid | 2-s2.0-37049023879 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31010 | - |
dc.identifier.url | https://www.molbiolcell.org/doi/10.1091/mbc.e07-03-0243 | - |
dc.identifier.wosid | 000251660800021 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC CELL BIOLOGY | - |
dc.title | Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | SYNAPTONEMAL COMPLEX | - |
dc.subject.keywordPlus | NUCLEAR REORGANIZATION | - |
dc.subject.keywordPlus | CHIASMA FORMATION | - |
dc.subject.keywordPlus | CROSSING-OVER | - |
dc.subject.keywordPlus | GENE FAMILY | - |
dc.subject.keywordPlus | SYNAPSIS | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS GERMLINE | - |
dc.subject.keywordPlus | DAMAGE-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | C-ELEGANS | - |
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