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김홍태

Kim, Hongtae
Cancer/DNA damage Lab.
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CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

Author(s)
Kim, HongtaeHuang, JunChen, Junjie
Issued Date
2007-08
DOI
10.1038/nsmb1277
URI
https://scholarworks.unist.ac.kr/handle/201301/24910
Fulltext
https://www.nature.com/articles/nsmb1277
Citation
NATURE STRUCTURAL & MOLECULAR BIOLOGY, v.14, no.8, pp.710 - 715
Abstract
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
Publisher
NATURE PUBLISHING GROUP
ISSN
1545-9985
Keyword
CHECKPOINTPHOSPHORYLATIONKINASEREPAIRROLESBRCA2MICECHK1

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