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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 715 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 710 | - |
dc.citation.title | NATURE STRUCTURAL & MOLECULAR BIOLOGY | - |
dc.citation.volume | 14 | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Huang, Jun | - |
dc.contributor.author | Chen, Junjie | - |
dc.date.accessioned | 2023-12-22T09:11:09Z | - |
dc.date.available | 2023-12-22T09:11:09Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2007-08 | - |
dc.description.abstract | The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response. | - |
dc.identifier.bibliographicCitation | NATURE STRUCTURAL & MOLECULAR BIOLOGY, v.14, no.8, pp.710 - 715 | - |
dc.identifier.doi | 10.1038/nsmb1277 | - |
dc.identifier.issn | 1545-9985 | - |
dc.identifier.scopusid | 2-s2.0-34547655427 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24910 | - |
dc.identifier.url | https://www.nature.com/articles/nsmb1277 | - |
dc.identifier.wosid | 000248555400008 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CHECKPOINT | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | BRCA2 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | CHK1 | - |
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