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김홍태
Kim, Hongtae

김홍태

Department of Biological Sciences(생명과학과)

Research Interests
Cancer;DNA damage response;DDR;CML;Chronic myelogenous leukemia;암;DNA 복구;DNA 손상 반응;만성골수성백혈병;백혈병
Lab Description
My lab focuses on studying the DNA damage response pathway and development/progression of chronic myeloid leukemia (CML). DNA damage responses are important in maintaining genetic stability in eukaryotic cells. Because many tumor suppressor proteins including ATM, ATR, MDC1, RNF8, RNF168, RAP80, BRCA1, and BRCA2 are involved in the DNA damage pathway, the complete understanding of this pathway is important in preventing neoplastic transformation. So, our laboratory’s goal is to understand the inherent genetic stability and molecular mechanisms of tumorigenesis by studying DNA damage signaling pathways. CML study is the second project in my Lab. My Lab has focused on identifying genes that are resistant to the tyrosine kinase inhibitor of CML. In addition, we are studying the molecular mechanisms of the discovered genes and applying them to CML patients. The aim of this research project is to ultimately contribute to the treatment and diagnosis of chronic myelogenous leukemia.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
REXO5 Promotes Genomic Integrity Through Regulating R-loop Using Its Exonuclease Activity File File

Lee, Ye Jin , Lee, Seo Yun , Kim, Soomi , Kim, Soo-Hyun , Lee, Soo Hyeon , Park, Sungho , Kim, Jae Jin , Kim, Dong-Wook , Kim, Hongtae

Article Issue Date2024-10 View73
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation File File

Hwang, Won Chan , Park, Kibeom , Park, Silvia , Cheon, Na Young , Lee, Ja Yil , Hwang, Taejoo , Lee, Semin , Lee, Jong-Mi , Ju, Min Kyung , Lee, Joo Rak , et al

Article Issue Date2024-06 View117
Direct visualization of replication and R-loop collision using single-molecule imaging File File

Kim, Subin , Shin, Woo Hee , Kang, Yujin , Kim, Hongtae , Lee, Ja Yil

Article Issue Date2024-01 View101
Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia File File

Shin, Ji Eun , Kim, Soo-Hyun , Kong, Mingyu , Kim, Hwa-Ryeon , Yoon, Sungmin , Kee, Kyung-Mi , Kim, Jung Ah , Kim, Dong Hyeon , Park, So Yeon , Park, Jae Hyung , et al

Article Issue Date2023-11 View63
Single-cell RNA Sequencing Reveals Novel Cellular Factors for Response to Immunosuppressive Therapy in Aplastic Anemia File File

Jang, Jinho , Kim, Hongtae , Park, Sung-Soo , Kim, Miok , Min, Yong Ki , Jeong, Hyoung-oh , Kim, Seunghoon , Hwang, Taejoo , Choi, David Whee-Young , Kim, Hee-Je , et al

Article Issue Date2023-11 View92
Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase File File

Kang, Yujin , Han, Ye Gi , Khim, Keon Woo , Choi, Woo Gyun , Ju, Min Kyung , Park, Kibeom , Shin, Kyeong Jin , Chae, Young Chan , Choi, Jang Hyun , Kim, Hongtae , et al

Article Issue Date2023-08 View82
MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1 File

Oh, Jung-Min , Kang, Yujin , Park, Jumi , Sung, Yubin , Kim, Dayoung , Seo, Yuri , Lee, EunA , Ra, JaeSun , Amarsanaa, Enkhzul , Park, Young-Un , et al

Article Issue Date2023-06 View96
ZNF212 promotes genomic integrity through direct interaction with TRAIP File File

Chung, Hee Jin , Lee, Joo Rak , Kim, Tae Moon , Kim, Soomi , Park, Kibeom , Kim, Myung-Jin , Jung, Eunyoung , Kim, Subin , Ra, Jae Sun , Hwang, Sunyoung , et al

Article Issue Date2023-01 View99
BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability File

Lee, Shin-Ai , Lee, Daye , Kang, Minhwa , Kim, Sora , Kwon, Su-Jung , Lee, Han-Sae , Seo, Hye-Ran , Kaushal, Prashant , Lee, Nam Soo , Kim, Hongtae , et al

Article Issue Date2022-12 View69
Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia File

Park, Kibeom , Yoo, Hee-Seop , Oh, Chang-Kyu , Lee, Joo Rak , Chung, Hee Jin , Kim, Ha-Neul , Kim, Soo-Hyun , Kee, Kyung-Mi , Kim, Tong Yoon , Kim, Myungshin , et al

Article Issue Date2022-11 View83
PWWP2B promotes DNA end resection and homologous recombination File

Ju, Min Kyung , Lee, Joo Rak , Choi, Yeonsong , Park, Seon Young , Sul, Hee Jung , Chung, Hee Jin , An, Soyeong , Lee, Semin , Jung, Eungyoung , Kim, Bohyun , et al

Article Issue Date2022-07 View112
Comparison of 3-month cytogenetic and molecular assays for early assessment of long-term clinical impact after BCR-ABL1 tyrosine kinase inhibitor treatment in chronic myeloid leukemia File

Kee, Kyung-Mi , Kim, Soo-Hyun , Yang, Seon-Young , Shin, Jeong-U , Nam, Yoon-Won , Jang, Eun-Jung , Kim, Hongtae , Lee, Semin , Park, Sung Ho , Kim, Dong-Wook

Article Issue Date2022-01 View61
Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA File

Lee, Yo Han , Jang, Hyun-Jun , Kim, Sounkou , Choi, Sun Sil , Khim, Keon Woo , Eom, Hye-Jin , Hyun, Jimin , Shin, Kyeong Jin , Chae, Young Chan , Kim, Hongtae , et al

Article Issue Date2021-12 View69
RNF126 is a positive regulator of TRAF3 ubiquitination File

Kim, Soomi , Park, Kibeom , Oh, Jung-Min , Kim, Hongtae

Article Issue Date2021-12 View66
USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing File File

Kim, Jae Jin , Lee, Seo Yun , Hwang, Yiseul , Kim, Soyeon , Chung, Jee Min , Park, Sangwook , Yoon, Junghyun , Yun, Hansol , Ji, Jae-Hoon , Chae, Sunyoung , et al

Article Issue Date2021-11 View54
Thrap3 promotes R-loop resolution via interaction with methylated DDX5 File

Kang, Hyun Je , Eom, Hye-jin , Kim, Hongtae , Myung, Kyungjae , Kwon, Hyug Moo , Choi, Jang Hyun

Article Issue Date2021-10 View148
NSMF promotes the replication stress-induced DNA damage response for genome maintenance File

Ju, Min Kyung , Shin, Kyeong Jin , Lee, Joo Rak , Khim, Keon Woo , Lee, Eun A , Ra, Jae Sun , Kim, Byung-Gyu , Jo, Han-seul , Yoon, Jong Hyuk , Kim, Tae Moon , et al

Article Issue Date2021-06 View66
TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution File File

Kang, Hyun Je , Cheon, Na Young , Park, Hyun , Jeong, Gyu Won , Ye, Byeong Jin , Yoo, Eun Jin , Lee, Jun Ho , Hur, Jin-Hoe , Lee, Eun-A , Kim, Hongtae , et al

Article Issue Date2021-01 View84
GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia File

Han, Seung Hun , Korm, Sovannarith , Han, Ye Gi , Choi, Soo-Young , Kim, Soo-Hyun , Chung, Hee Jin , Park, Kibeom , Kim, Jae-Young , Myung, Kyungjae , Lee, Joo-Yong , et al

Article Issue Date2019-12 View96
TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways File

Han, Ye Gi , Yun, Miyong , Choi, Minji , Lee, Seok-Geun , Kim, Hongtae

Article Issue Date2019-06 View66
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