BROWSE

Related Researcher

Author's Photo

Myung, Kyungjae
Center for Genomic Integrity
Research Interests
  • DNA Replication, DNA Repair, DNA Recombination, DNA Damage Response, cancer, aging

ITEM VIEW & DOWNLOAD

SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats
Author
Lee, DeokjaePark, Jun HongKim, ShinseogLee, Seon-gyeongMyung, Kyungjae
Issue Date
2018-01
Publisher
TAYLOR & FRANCIS INC
Citation
TRANSCRIPTION-AUSTIN, v.9, no.3, pp.190 - 195
Abstract
There are hundreds of copies of rDNA repeats in mammalian chromosomes and the ratio of active, poised, or inactive rDNA is regulated in epigenetic manners. Recent studies demonstrated that a post-DNA replication repair enzyme, SHPRH affects rRNA transcription by recognizing epigenetic markers on rDNA promoters and unveiled potential links between DNA repair and ribosome biogenesis. This study suggests that SHPRH could be a link between mTOR-mediated epigenetic regulations and rRNA transcription, while concomitantly affecting genomic integrity.
URI
https://scholarworks.unist.ac.kr/handle/201301/24526
URL
https://www.tandfonline.com/doi/full/10.1080/21541264.2017.1381795
DOI
10.1080/21541264.2017.1381795
ISSN
2154-1264
Appears in Collections:
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU