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ScharerDavid Orlando

Scharer, Orlando D.
Schärer Lab.
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Generation of DNA Interstrand Cross-Links by Post-Synthetic Reductive Amination

Author(s)
Angelov, TodorGuainazzi, AngeloSchaerer, Orlando D.
Issued Date
2009-02
DOI
10.1021/ol802719a
URI
https://scholarworks.unist.ac.kr/handle/201301/21269
Fulltext
http://pubs.acs.org/doi/abs/10.1021/ol802719a
Citation
ORGANIC LETTERS, v.11, no.3, pp.661 - 664
Abstract
DNA interstrand cross-links (ICLs) are the clinically most relevant adducts formed by many antitumor agents. To facilitate the study of biological responses triggered by ICLs, we developed a new approach toward the synthesis of mimics of nitrogen mustard ICLs. 7-Deazaguanine residues bearing acetaldehyde groups were incorporated into complementary strands of DNA and cross-link formation induced by double reductive amination. Our strategy enables the synthesis of major groove cross-links in high yields and purity.
Publisher
AMER CHEMICAL SOC
ISSN
1523-7060
Keyword
DUPLEX DNASTRUCTURAL-CHARACTERIZATIONDEOXYGUANOSINE RESIDUESOLIGONUCLEOTIDESREPAIRMODELNUCLEOTIDEAGENTS

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