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DC Field | Value | Language |
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dc.citation.endPage | 664 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 661 | - |
dc.citation.title | ORGANIC LETTERS | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Angelov, Todor | - |
dc.contributor.author | Guainazzi, Angelo | - |
dc.contributor.author | Schaerer, Orlando D. | - |
dc.date.accessioned | 2023-12-22T08:09:21Z | - |
dc.date.available | 2023-12-22T08:09:21Z | - |
dc.date.created | 2017-01-26 | - |
dc.date.issued | 2009-02 | - |
dc.description.abstract | DNA interstrand cross-links (ICLs) are the clinically most relevant adducts formed by many antitumor agents. To facilitate the study of biological responses triggered by ICLs, we developed a new approach toward the synthesis of mimics of nitrogen mustard ICLs. 7-Deazaguanine residues bearing acetaldehyde groups were incorporated into complementary strands of DNA and cross-link formation induced by double reductive amination. Our strategy enables the synthesis of major groove cross-links in high yields and purity. | - |
dc.identifier.bibliographicCitation | ORGANIC LETTERS, v.11, no.3, pp.661 - 664 | - |
dc.identifier.doi | 10.1021/ol802719a | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.scopusid | 2-s2.0-60849106672 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21269 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/ol802719a | - |
dc.identifier.wosid | 000262913500042 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Generation of DNA Interstrand Cross-Links by Post-Synthetic Reductive Amination | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DUPLEX DNA | - |
dc.subject.keywordPlus | STRUCTURAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | DEOXYGUANOSINE RESIDUES | - |
dc.subject.keywordPlus | OLIGONUCLEOTIDES | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | NUCLEOTIDE | - |
dc.subject.keywordPlus | AGENTS | - |
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