ScharerDavid Orlando
Scharer, Orlando D.

ScharerDavid Orlando

Graduate School of Health Science and Technology(의과학대학원)

  • Schärer Lab.
Research Interests
Biochemistry;Genetics;Molecular biology;Cancer Chemotherapy;Genomic Integrity;DNA Repair;DNA Damage;Cisplatin;Nucleotide Excision Repair;DNA Interstrand Crosslink Repair;Personalized Medicine;NER;생화학생화학;유전학;분자생물학;항암화학요법;DNA 복구
Lab Description
We are an international and interdisciplinary research team focused on the study to the molecular pathways underlying DNA repair and the DNA damage response and its connection to tumorigenesis and cancer therapy. Our research combines biochemical, molecular, cellular structural and biology with organic chemistry and genetics. We study a variety of DNA repair pathways, including nucleotide excision repair (NER) and interstrand crosslink (ICL) repair as well as responses to replication stress and doublestrand break (DSB) formation. Our studies aim to elucidate the mechanisms by these pathways prevent tumorigenesis and the inherited genetic disorders xeroderma pigmentosum (XP) and Fanconi anemia (FA) and conversely, how they may be targeted in cancer therapy to target the inherent vulnerabilities of tumors and to improve outcomes of treatment by agents such as cisplatin.
* Specific Research Areas1. Chemical Approaches for Studying DNA Repair Pathways2. Molecular Mechanisms of Human Nucleotide Excision Repair (NER)3. Mechanistic Basis of Resistance and Diagnostic Tools for Platinum Anticancer Therapy4. Hijacking Transcription-Coupled Nucleotide Excision Repair for Cancer Therapy

Oh, Jung-MinKang, YujinPark, JumiSung, YubinKim, DayoungSeo, YuriLee, EunARa, JaeSunAmarsanaa, EnkhzulPark, Young-Un , et al

Article Issue Date2023-06 View17

Apelt, KatjaLans, HannesScharer, Orlando D.Luijsterburg, Martijn S.

Article Issue Date2021-12 View14

von Werdt, AlexanderBrandt, LauraScharer, Orlando D.Rubin, Mark A.

Article Issue Date2021-10 View10

Cheun, Young K.Groehler, Arnold S.Schaerer, Orlando D.

Article Issue Date2021-07 View17

Tsao, NingScharer, Orlando D.Mosammaparast, Nima

Article Issue Date2021-03 View14
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