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Kim, Jae-Ick
Neural Circuit and Neurodegenerative Disease Lab.
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Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum

Author(s)
Wu, Yu-WeiKim, Jae-IckTawfik, Vivianne L.Lalchandani, Rupa R.Scherrer, GregoryDing, Jun B.
Issued Date
2015-01
DOI
10.1016/j.celrep.2014.12.005
URI
https://scholarworks.unist.ac.kr/handle/201301/20950
Fulltext
http://www.sciencedirect.com/science/article/pii/S221112471401016X
Citation
CELL REPORTS, v.10, no.1, pp.75 - 87
Abstract
Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic plasticity expressed at these glutamatergic inputs; however, whether eCB-LTD can be induced at all inputs on all striatal neurons is still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. We found that eCB-LTD was successfully induced at corticostriatal synapses, independent of postsynaptic striatal spiny projection neuron (SPN) subtype. Conversely, eCB-LTD was only nominally present at thalamostriatal synapses. This dichotomy was attributable to the minimal expression of cannabinoid type 1 (CB1) receptors on thalamostriatal terminals. Furthermore, coactivation of dopamine receptors on SPNs during LTD induction re-established SPN-subtype-dependent eCB-LTD. Altogether, our findings lay the groundwork for understanding corticostriatal and thalamostriatal synaptic plasticity and for striatal eCB-LTD in motor learning.
Publisher
Cell Press
ISSN
2211-1247
Keyword
LONG-TERM DEPRESSIONMEDIUM SPINY NEURONSLIGHT-INDUCED ACTIVATIONBASAL GANGLIA CIRCUITPARKINSONS-DISEASETRANSGENIC MICECORTICOSTRIATAL SYNAPSESSYNAPTIC-TRANSMISSIONDOPAMINERGIC CONTROLRECEPTOR ACTIVATION

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