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DC Field | Value | Language |
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dc.citation.endPage | 87 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Wu, Yu-Wei | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Tawfik, Vivianne L. | - |
dc.contributor.author | Lalchandani, Rupa R. | - |
dc.contributor.author | Scherrer, Gregory | - |
dc.contributor.author | Ding, Jun B. | - |
dc.date.accessioned | 2023-12-22T01:42:12Z | - |
dc.date.available | 2023-12-22T01:42:12Z | - |
dc.date.created | 2016-12-08 | - |
dc.date.issued | 2015-01 | - |
dc.description.abstract | Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic plasticity expressed at these glutamatergic inputs; however, whether eCB-LTD can be induced at all inputs on all striatal neurons is still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. We found that eCB-LTD was successfully induced at corticostriatal synapses, independent of postsynaptic striatal spiny projection neuron (SPN) subtype. Conversely, eCB-LTD was only nominally present at thalamostriatal synapses. This dichotomy was attributable to the minimal expression of cannabinoid type 1 (CB1) receptors on thalamostriatal terminals. Furthermore, coactivation of dopamine receptors on SPNs during LTD induction re-established SPN-subtype-dependent eCB-LTD. Altogether, our findings lay the groundwork for understanding corticostriatal and thalamostriatal synaptic plasticity and for striatal eCB-LTD in motor learning. | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.10, no.1, pp.75 - 87 | - |
dc.identifier.doi | 10.1016/j.celrep.2014.12.005 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.scopusid | 2-s2.0-84920934188 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20950 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S221112471401016X | - |
dc.identifier.wosid | 000347465600008 | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | MEDIUM SPINY NEURONS | - |
dc.subject.keywordPlus | LIGHT-INDUCED ACTIVATION | - |
dc.subject.keywordPlus | BASAL GANGLIA CIRCUIT | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | CORTICOSTRIATAL SYNAPSES | - |
dc.subject.keywordPlus | SYNAPTIC-TRANSMISSION | - |
dc.subject.keywordPlus | DOPAMINERGIC CONTROL | - |
dc.subject.keywordPlus | RECEPTOR ACTIVATION | - |
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