Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobe
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- Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobe
- Moon, Hyojin; Lee, Jisu; Kim, Hansol; Heo, Somin; Min, Junseon; Kang, Sebyung
- Issue Date
- BIOMATERIALS RESEARCH, v.18, pp.21
- Background - Protein cage nanoparticles are promising nanoplatform candidates for efficient delivery systems of diagnostics and/or therapeutics because of their uniform size and structure as well as high biocompatibility and biodegradability. Encapsulin protein cage nanoparticle is used to develop a cell-specific targeting optical nanoprobe.
Results - FcBPs are genetically inserted and successfully displayed on the surface of encapsulin to form FcBP-encapsulin. Selectively binding of FcBP-encapsulin to SCC-7 is visualized with fluorescent microscopy.
Conclusions - Encapsulin protein cage nanoparticle is robust enough to maintain their structure at high temperature and easily acquires multifunctions on demand through the combination of genetic and chemical modifications.
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- BIO_Journal Papers
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