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Kang, Sebyung
Protein Nanobio Lab
Research Interests
  • Protein engineering, Drug/diagnostics delivery nanoplatform, Protein-base vaccine delivery systems, Biosensor & imaging

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Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobe

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Title
Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobe
Author
Moon, HyojinLee, JisuKim, HansolHeo, SominMin, JunseonKang, Sebyung
Issue Date
2014-11
Publisher
한국생체재료학회
Citation
BIOMATERIALS RESEARCH, v.18, pp.21
Abstract
Background - Protein cage nanoparticles are promising nanoplatform candidates for efficient delivery systems of diagnostics and/or therapeutics because of their uniform size and structure as well as high biocompatibility and biodegradability. Encapsulin protein cage nanoparticle is used to develop a cell-specific targeting optical nanoprobe. Results - FcBPs are genetically inserted and successfully displayed on the surface of encapsulin to form FcBP-encapsulin. Selectively binding of FcBP-encapsulin to SCC-7 is visualized with fluorescent microscopy. Conclusions - Encapsulin protein cage nanoparticle is robust enough to maintain their structure at high temperature and easily acquires multifunctions on demand through the combination of genetic and chemical modifications.
URI
https://scholarworks.unist.ac.kr/handle/201301/20623
URL
https://biomaterialsres.biomedcentral.com/articles/10.1186/2055-7124-18-21
DOI
10.1186/2055-7124-18-21
ISSN
2055-7124
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BME_Journal Papers
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