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강세병
Kang, Sebyung

강세병

생명과학과

Research Interests
Nanobiotechnology;Protein Engineering;Protein Nanoparticle-based Drug Delivery;Biosensors;Bioimaging;바이오 센서;바이오 이미징;나노바이오기술;단백질 공학;단백질 나노입자;세포질내 단백질 전달
Lab Description
Our researches focus on utilizing protein based nanobio-templates for biomedical and biomaterial applications. To achieve these goals, we are using various types of nanobio-templates, such as viral capsids, small protein cages, and functional proteins, and biophysical and biochemical methods to elucidate their functions.
1. Protein Cage EngineeringProtein cage architecture has three modifiable surfaces; exterior, interior and subunit-subunit interfaces. These surfaces can be modified both genetically and chemically on demand. We can engineer these three surfaces for the purposes listed below by design.
 2. Targeted Delivery of Therapeutic or Diagnostic ReagentsNanobio-templates can be utilized as multivalent and targeted delivery vehicles through genetic and chemical modifications. Well defined 3-D structure and multiple addressible sites are beneficial for multi-functional nanoplatforms.
3. Protein engineering: Biosensings & Imaging Binding specificity and high affinity to any given target molecule are essential features for in vitro and/or in vivo diagnostics and for many other biotechnological and biomedical applications. Protein engineering allows constructing multifunctional biosensing & imaging components.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
HER2-Targeting and TRAIL-Presenting Protein Nanoparticles Induce a Concentration-Dependent Biphasic Response in HER2-Positive Breast Cancer Cells File

Jeong, Diane , Kim, Junsu , Kim, Yunjung , Jun, Heejin , Eom, Soomin , Kang, Sebyung

Article Issue Date2026-02 View19
Targeted Therapy for CD13-Overexpressing Triple-Negative Breast Cancers Using Apoptosis-Inducing Protein Cage Nanoparticles File File

Jun, Heejin , Kim, Junsu , Eom, Soomin , Jeong, Diane , Kang, Sebyung

Article Issue Date2026-02 View8
Compact clustering of highly oligomerized anti-DR5 nanobodies effectively drives apoptotic cancer cell death, significantly suppressing tumor growth File

Kim, Yunjung , Mun, Jihyoung , Kim, Eojin , Roh, Hyungsuk , Eom, Soomin , Jun, Heejin , Kim, Hyo Jeong , Kim, Minseung , Jeon, Jun Pyo , Park, Sung Ho , et al

Article Issue Date2025-12 View13774
Effective in vivo delivery of diphtheria toxin using protein cage nanoparticles for targeted cancer therapy File

Eom, Soomin , Park, Seong Guk , Jun, Heejin , Kim, Yunjung , Lee, Hyun Bin , Kang, Sebyung

Article Issue Date2025-08 View80
Targeting RBM39 with Tasisulam enhances TRAIL-induced apoptosis through DR5 upregulation and Bcl-2 downregulation in renal cell carcinoma File

Jang, Ji Hoon , Kim, Haein , Jun, Heejin , Park, Cho-Young , Kim, Joo-Young , Shin, Yerim , Yeo, Mirae , Kim, Hunmin , Kang, Sebyung , Kim, Eunhee , et al

Article Issue Date2025-06 View200
CD7-Targeted Cytotoxic Potency of Diphtheria Toxin- and Ricin-Based Immunotoxins in Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia File

Lee, Hyun Bin , Park, Seong Guk , Kim, Hyo Jeong , Jeon, Jun Pyo , Oh, SuHyeon , Lee, SangJoon , Park, Sung Ho , Kang, Sebyung

Article Issue Date2025-06 View178
EGFR Affibody and PEG functionalized protein nanoparticles: Sustaining targeting and macrophage evasion File

Jang, Seonhye , Jun, Heejin , Eom, Soomin , Zhao, Sheng , Murthy, Niren , Kang, Sebyung , Kim, Hansol

Article Issue Date2025-05 View153
Protein Nanoparticles Simultaneously Displaying TRAIL and EGFR-Binding Ligands Effectively Induce Apoptotic Cancer Cell Death and Overcome EGFR-TKI Resistance in Lung Cancer File

Kim, Yunjung , Kim, Jiwoo , Eom, Soomin , Jun, Heejin , Lee, Hyun Bin , Jeong, Diane , Kang, Sebyung

Article Issue Date2025-04 View97
In situ forming and self-crosslinkable protein hydrogels for localized cancer therapy and topical wound healing File

Eom, Soomin , Park, Seong Guk , Koo, Yonghoe , Noh, Yeongjin , Choi, Cholong , Kim, Yunjung , Jun, Heejin , Cha, Chaenyung , Joo, Jinmyoung , Kang, Sebyung

Article Issue Date2025-02 View141
CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic cell death of acute myeloid leukemia, prolonging survival in mouse models File

Jun, Heejin , Yeo, Mirae , Jeon, Jun Pyo , Eom, Soomin , Kim, Hyo Jeong , Kim, Yunjung , Jang, Eunjung , Park, Sung Ho , Kim, Eunhee , Kang, Sebyung

Article Issue Date2024-12 View294
Developing Porous Protein Cage Nanoparticles as Cargo-Loadable and Ligand-Displayable Modular Delivery Nanoplatforms File

Eom, Soomin , Jun, Heejin , Kim, Eojin , Min, Duyoung , Kim, Hansol , Kang, Sebyung

Article Issue Date2024-10 View171
Development of plug-and-deliverable intracellular protein delivery platforms based on botulinum neurotoxin File

Park, Seong Guk , Lee, Hyun Bin , Kang, Sebyung

Article Issue Date2024-03 View158
Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites and suppress tumor growth File

Park, Seong Guk , Kim, Hyo Jeong , Lee, Hyun Bin , Eom, Soomin , Jun, Heejin , Jang, Yeongim , Park, Sung Ho , Kang, Sebyung

Article Issue Date2024-02 View155
Compact and modular bioprobe: Integrating SpyCatcher/SpyTag recombinant proteins with zwitterionic polymer-coated quantum dots File

Kim, Sunghwan , Bae, Yoonji , Park, Sung Han , Chen, Ning , Eom, Soomin , Kang, Sebyung , Park, Jongnam

Article Issue Date2023-12 View255
Development of recombinant secondary antibody mimics (rSAMs) for immunoassays through genetic fusion of monomeric alkaline phosphatase with antibody binders File

Park, Jiyeon , Bae, Yoonji , Eom, Soomin , Choi, Yuha , Lee, Giwook , Kang, Sebyung

Article Issue Date2023-11 View179
Lactate oxidase/vSIRPα conjugates efficiently consume tumor-produced lactates and locally produce tumor-necrotic H2O2 to suppress tumor growth File

Kang, Yujin , Yeo, Mirae , Choi, Hyukjun , Jun, Heejin , Eom, Soomin , Park, Seong Guk , Yoon, Haejin , Kim, Eunhee , Kang, Sebyung

Article Issue Date2023-03 View233
Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth File File

Choi, Hyukjun , Yeo, Mirae , Kang, Yujin , Kim, Hyo Jeong , Park, Seong Guk , Jang, Eunjung , Park, Sung Ho , Kim, Eunhee , Kang, Sebyung

Article Issue Date2023-01 View198
Tunable Physicomechanical and Drug Release Properties of In Situ Forming Thermoresponsive Elastin-like Polypeptide Hydrogels File

Lee, Kangseok , Noh, Yeongjin , Bae, Yoonji , Kang, Sebyung , Cha, Chaenyung

Article Issue Date2022-12 View159
Highly sensitive pregnancy test kit via oriented antibody conjugation on brush-type ligand-coated quantum beads File

Kim, Sunghwan , Ahn, Yujin , Bae, Yoonji , Woo, Sunyoung , Park, Jungsik , Han, Im kyung , Kim, Hyunhong , Eom, Soomin , Kang, Sebyung , Jung, Woonggyu , et al

Article Issue Date2022-10 View242
TRAIL & EGFR affibody dual-display on a protein nanoparticle synergistically suppresses tumor growth File

Jun, Heejin , Jang, Eunjung , Kim, Hansol , Yeo, Mirae , Park, Seong Guk , Lee, Jaehyeok , Shin, Kyeong Jin , Chae, Young Chan , Kang, Sebyung , Kim, Eunhee

Article Issue Date2022-09 View222
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