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Ko, Myunggon
Cancer Epigenetics Lab.
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DNA methylation and hydroxymethylation in hematologic differentiation and transformation

Author(s)
Ko, MyunggonAn, JungeunRao, Anjana
Issued Date
2015-12
DOI
10.1016/j.ceb.2015.10.009
URI
https://scholarworks.unist.ac.kr/handle/201301/17917
Fulltext
http://www.sciencedirect.com/science/article/pii/S0955067415001301
Citation
CURRENT OPINION IN CELL BIOLOGY, v.37, pp.91 - 101
Abstract
Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.
Publisher
CURRENT BIOLOGY LTD
ISSN
0955-0674
Keyword
HEMATOPOIETIC STEM-CELLSACUTE MYELOID-LEUKEMIAMETHYLCYTOSINE OXIDASES TET1SELF-RENEWALMYELODYSPLASTIC SYNDROMES5-METHYLCYTOSINE OXIDATIONENHANCER ACTIVITYTUMOR-SUPPRESSORDNMT3A MUTATIONSGENE-EXPRESSION

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