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고명곤

Ko, Myunggon
Cancer Epigenetics Lab.
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dc.citation.endPage 101 -
dc.citation.startPage 91 -
dc.citation.title CURRENT OPINION IN CELL BIOLOGY -
dc.citation.volume 37 -
dc.contributor.author Ko, Myunggon -
dc.contributor.author An, Jungeun -
dc.contributor.author Rao, Anjana -
dc.date.accessioned 2023-12-22T00:36:18Z -
dc.date.available 2023-12-22T00:36:18Z -
dc.date.created 2015-12-01 -
dc.date.issued 2015-12 -
dc.description.abstract Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved. -
dc.identifier.bibliographicCitation CURRENT OPINION IN CELL BIOLOGY, v.37, pp.91 - 101 -
dc.identifier.doi 10.1016/j.ceb.2015.10.009 -
dc.identifier.issn 0955-0674 -
dc.identifier.scopusid 2-s2.0-84947249842 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/17917 -
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0955067415001301 -
dc.identifier.wosid 000367112800013 -
dc.language 영어 -
dc.publisher CURRENT BIOLOGY LTD -
dc.title DNA methylation and hydroxymethylation in hematologic differentiation and transformation -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Cell Biology -
dc.relation.journalResearchArea Cell Biology -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus HEMATOPOIETIC STEM-CELLS -
dc.subject.keywordPlus ACUTE MYELOID-LEUKEMIA -
dc.subject.keywordPlus METHYLCYTOSINE OXIDASES TET1 -
dc.subject.keywordPlus SELF-RENEWAL -
dc.subject.keywordPlus MYELODYSPLASTIC SYNDROMES -
dc.subject.keywordPlus 5-METHYLCYTOSINE OXIDATION -
dc.subject.keywordPlus ENHANCER ACTIVITY -
dc.subject.keywordPlus TUMOR-SUPPRESSOR -
dc.subject.keywordPlus DNMT3A MUTATIONS -
dc.subject.keywordPlus GENE-EXPRESSION -

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