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Ko, Myunggon
Molecular Immunology & Cancer Epigenetics
Research Interests
  • TET proteins, DNA hydroxymethylation, oncogenesis, cancer stem cells, cancer therapy

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The SWI/SNF-like BAF complex is essential for early B cell development

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Title
The SWI/SNF-like BAF complex is essential for early B cell development
Author
Choi, JinwookKo, MyunggonJeon, ShinJeon, YoonPark, KyungsooLee, ChangjinLee, HoSeong, Rho H
Keywords
CHROMATIN-REMODELING COMPLEXES; COMMON LYMPHOID PROGENITORS; MOUSE BONE-MARROW; LINEAGE COMMITMENT; PROTEASOMAL DEGRADATION; UP-REGULATION; PRO-B; GENE; TRANSCRIPTION; EXPRESSION
Issue Date
2012-04
Publisher
AMER ASSOC IMMUNOLOGISTS
Citation
JOURNAL OF IMMUNOLOGY, v.188, no.8, pp.3791 - 3803
Abstract
During the process of B cell development, transcription factors, such as E2A and Ebf1, have been known to play key roles. Although transcription factors and chromatin regulators work in concert to direct the expression of B lineage-specific genes, little is known about the involvement of regulators for chromatin structure during B lymphopoiesis. In this article, we show that deletion of Srg3/mBaf155, a scaffold subunit of the SWI/SNF-like BAF complex, in the hematopoietic lineage caused defects at both the common lymphoid progenitor stage and the transition from pre–pro-B to early pro-B cells due to failures in the expression of B lineage-specific genes, such as Ebf1 and Il7ra, and their downstream target genes. Moreover, mice that were deficient in the expression of Brg1, a subunit of the complex with ATPase activity, also showed defects in early B cell development. We also found that the expression of Ebf1 and Il7ra is directly regulated by the SWI/SNF-like BAF complex. Thus, our results suggest that the SWI/SNF-like BAF complex facilitates early B cell development by regulating the expression of B lineage-specific genes.
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DOI
10.4049/jimmunol.1103390
ISSN
0022-1767
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PHY_Journal Papers
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