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DC Field | Value | Language |
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dc.citation.endPage | 3803 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3791 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 188 | - |
dc.contributor.author | Choi, Jinwook | - |
dc.contributor.author | Ko, Myunggon | - |
dc.contributor.author | Jeon, Shin | - |
dc.contributor.author | Jeon, Yoon | - |
dc.contributor.author | Park, Kyungsoo | - |
dc.contributor.author | Lee, Changjin | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Seong, Rho H | - |
dc.date.accessioned | 2023-12-22T05:12:09Z | - |
dc.date.available | 2023-12-22T05:12:09Z | - |
dc.date.created | 2015-07-24 | - |
dc.date.issued | 2012-04 | - |
dc.description.abstract | During the process of B cell development, transcription factors, such as E2A and Ebf1, have been known to play key roles. Although transcription factors and chromatin regulators work in concert to direct the expression of B lineage-specific genes, little is known about the involvement of regulators for chromatin structure during B lymphopoiesis. In this article, we show that deletion of Srg3/mBaf155, a scaffold subunit of the SWI/SNF-like BAF complex, in the hematopoietic lineage caused defects at both the common lymphoid progenitor stage and the transition from pre-pro-B to early pro-B cells due to failures in the expression of B lineage-specific genes, such as Ebf1 and Il7ra, and their downstream target genes. Moreover, mice that were deficient in the expression of Brg1, a subunit of the complex with ATPase activity, also showed defects in early B cell development. We also found that the expression of Ebf1 and Il7ra is directly regulated by the SWI/SNF-like BAF complex. Thus, our results suggest that the SWI/SNF-like BAF complex facilitates early B cell development by regulating the expression of B lineage-specific genes. | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.188, no.8, pp.3791 - 3803 | - |
dc.identifier.doi | 10.4049/jimmunol.1103390 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.scopusid | 2-s2.0-84860347851 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/12564 | - |
dc.identifier.url | http://www.jimmunol.org/content/188/8/3791.long | - |
dc.identifier.wosid | 000302641400026 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | The SWI/SNF-like BAF complex is essential for early B cell development | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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