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A novel TRAP1 inhibitor, containing flexible triphenylphosphonium, interacted with an allosteric site involving E403 residue and triggered protein conformational changes

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2018-10-20 View15

A novel TRAP1 inhibitor, UB-010 potently inactivates the mitochondrial chaperoneby interacting with the client binding site.

Yoon, Nam Gu , Hu, Sung , Kim. So-Yeon , Lee, Changwook , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View11

Anticancer strategy targeting mitochondrial Hsp90 in breast tumor envionment

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2023-09-15 View7

Caspase-3 has enhanced proteolytic properties at acidic pH

Kang, Byoung Heon

Conference Paper Issue Date2002 View8

Characterization of active-site residues of the NIa protease from tobacco vein mottling virus File

Hwang, DC , Kim, DH , Lee, JS , Kang, Byoung Heon , Han, J , Kim, W , Song, BD , Choi, KY

Article Issue Date2000-10 View18

Characterization of Nla protease from turnip mosaic potyvirus exhibiting a low-temperature optimum catalytic activity File

Kim, DH , Hwang, D , Kang, Byoung Heon , Lew, J , Choi, KY

Article Issue Date1996-07 View20

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer drug: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam gu , Jung, Hyun suck , Han, In cheol , Kang, Byoung Heon

Conference Paper Issue Date2017-05-18 View9

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer therapeutics: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2017-04-03 View7

Combination effect on Gamitrinib-TPP on tamoxifen-resistant breast cancer cell line

Kang, Byoung Heon , None

Conference Paper Issue Date2013 View8

Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim File File

Park, Hye-Kyung , Lee, Ji-Eun , Lim, Jaehwa , Jo, Da-Eun , Park, Soo-Ah , Suh, Pann-Ghill , Kang, Byoung Heon

Article Issue Date2014-06 View50

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 File

Kang, Byoung Heon , Plescia, Janet , Song, Ho Young , Meli, Massimiliano , Colombo, Giorgio , Beebe, Kristin , Scroggins, Bradley , Neckers, Len , Altieri, Dario C.

Article Issue Date2009-03 View20

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones File

Kang, Byoung Heon , Altieri, D. C.

Article Issue Date2009-10 View9

Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors File

Kang, Byoung Heon , Jeong, Hanbin , Lee, Changwook

Article Issue Date2014-12 View18

Cyclophilin D defect impairs ROS regulation and increases invasion of cancer cells

Park,Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2017-05-31 View17

Cytotoxic effects of Tenebrio molitor larval extracts against hepatocellular carcinoma File

Lee, ji-Eun , Lee, An-Jung , Jo, Da-Eun , Cho, Ju Hyeong , Youn, Kumju , Yun, Eun-Young , Hwang, Jae-Sam , Jun, Mira , Kang, Byoung Heon

Article Issue Date2015-02 View18

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity File

Yang, Sujae , Yoon, Nam Gu , Kim, Dongyoung , Park, Eunsun , Kim, So-Yeon , Lee, Ji Hoon , Lee, Changwook , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2021-07 View27

Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 File

Lee, Changwook , Park, Hye-Kyung , Jeong, Hanbin , Lim, Jaehwa , Lee, An-Jung , Cheon, Keun Young , Kim, Chul-Su , Thomas, Ajesh P. , Bae, Boram , Kim, Nam Doo , et al

Article Issue Date2015-04 View27

Development of Hsp90 family protein inhibitors

Park, Hye-Kyung , Ko, Eunhwa , Lee, Geumwoo , Lee, Ji-Eun , Lee, Sang Kwang , Jeong, Hanbin , Lee, An-Jung , Im, Jin Young , Kim, Seong Heon , Lee, Changwook , et al

Conference Paper Issue Date2016-12-09 View8

Development of Hsp90 paralog specific inhibitors with mitochondrial drug delivery system

Kang, Byoung Heon

Conference Paper Issue Date2015-11-12 View5

Development of Hsp90 paralog specific inhibitors with mitochondrial drug delivery system File

Kang, Byoung Heon

Conference Paper Issue Date2015-04-18 View5

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