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ScharerDavid Orlando
Scharer, Orlando D.

ScharerDavid Orlando

Graduate School of Health Science and Technology(의과학대학원)

  • Schärer Lab.
Research Interests
Biochemistry;Genetics;Molecular biology;Cancer Chemotherapy;Genomic Integrity;DNA Repair;DNA Damage;Cisplatin;Nucleotide Excision Repair;DNA Interstrand Crosslink Repair;Personalized Medicine;NER;생화학생화학;유전학;분자생물학;항암화학요법;DNA 복구
Lab Description
We are an international and interdisciplinary research team focused on the study to the molecular pathways underlying DNA repair and the DNA damage response and its connection to tumorigenesis and cancer therapy. Our research combines biochemical, molecular, cellular structural and biology with organic chemistry and genetics. We study a variety of DNA repair pathways, including nucleotide excision repair (NER) and interstrand crosslink (ICL) repair as well as responses to replication stress and doublestrand break (DSB) formation. Our studies aim to elucidate the mechanisms by these pathways prevent tumorigenesis and the inherited genetic disorders xeroderma pigmentosum (XP) and Fanconi anemia (FA) and conversely, how they may be targeted in cancer therapy to target the inherent vulnerabilities of tumors and to improve outcomes of treatment by agents such as cisplatin.
* Specific Research Areas1. Chemical Approaches for Studying DNA Repair Pathways2. Molecular Mechanisms of Human Nucleotide Excision Repair (NER)3. Mechanistic Basis of Resistance and Diagnostic Tools for Platinum Anticancer Therapy4. Hijacking Transcription-Coupled Nucleotide Excision Repair for Cancer Therapy
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy File

Slyskova, Jana , Muniesa-Vargas, Alba , daSilva, IsraelTojal , Drummond, Rodrigo , Park, Jiyeong , Häckes, David , Poetsch, Isabella , Ribeiro-Silva, Cristina , Moretton, Amandine , Heffeter, Petra , et al

Article Issue Date2023-12 View16
Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors File File

Wie, Minwoo , Khim, Keon Woo , Groehler Iv, Arnold S , Heo, Soomin , Woo, Junhyeok , Son, Kook , Lee, Eun A , Ra, Jae Sun , Hong, Sung You , Scharer, Orlando D. , et al

Article Issue Date2023-09 View13
MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1 File

Oh, Jung-Min , Kang, Yujin , Park, Jumi , Sung, Yubin , Kim, Dayoung , Seo, Yuri , Lee, EunA , Ra, JaeSun , Amarsanaa, Enkhzul , Park, Young-Un , et al

Article Issue Date2023-06 View17
Development of Comprehensive Ultraperformance Liquid Chromatography-High-Resolution Mass Spectrometry Assays to Quantitate Cisplatin-Induced DNA-DNA Cross-Links File

Groehler, Arnold S. , Maratova, Asema , Dao, Nhat Mai , Mahkmut, Anuar , Scharer, Orlando D.

Article Issue Date2023-05 View17
EEPD1 promotes repair of oxidatively-stressed replication forks File File

Jaiswal, Aruna S. , Kim, Hyun-Suk , Scharer, Orlando D. , Sharma, Neelam , Williamson, Elizabeth A. , Srinivasan, Gayathri , Phillips, Linda , Kong, Kimi , Arya, Shailee , Misra, Anurag , et al

Article Issue Date2023-03 View6
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair File File

van den Heuvel, Diana , Kim, Mihyun , Wondergem, Annelotte P. , van der Meer, Paula J. , Witkamp, Myrèse , Lambregtse, Ferdy , Kim, Hyun-Suk , Kan, Folkert , Apelt, Katja , Kragten, Angela , et al

Article Issue Date2023-03 View16
ZNF212 promotes genomic integrity through direct interaction with TRAIP File File

Chung, Hee Jin , Lee, Joo Rak , Kim, Tae Moon , Kim, Soomi , Park, Kibeom , Kim, Myung-Jin , Jung, Eunyoung , Kim, Subin , Ra, Jae Sun , Hwang, Sunyoung , et al

Article Issue Date2023-01 View15
Polycarcin V induces DNA damage response and enables the profiling of DNA-binding proteins File

Yue, Zongwei , Wu, Fan , Guo, Fusheng , Park, Jiyeong , Wang, Jin , Zhang, Liyun , Liao, Daohong , Li, Wenyang , Scharer, Orlando D. , Lei, Xiaoguang

Article Issue Date2022-11 View14
Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair File

Kim, Mihyun , Kim, Hyun-Suk , D'Souza, Areetha , Gallagher, Kaitlyn , Jeong, Eunwoo , Le Meur, Kateryna Ogorodnik , Tsai, Chi-Lin , Tsai, Miaw-Sheue , Kee, Minyong , Tainer, John A. , et al

Article Issue Date2022-08 View9
XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair File File

Blessing, Charlotte , Apelt, Katja , van den Heuvel, Diana , Gonzalez-Leal, Claudia , Rother, Magdalena B. , van der Woude, Melanie , Gonzalez-Prieto, Roman , Yifrach, Adi , Parnas, Avital , Shah, Rashmi G. , et al

Article Issue Date2022-08 View8
Transcriptional Perturbations of 2,6-Diaminopurine and 2-Aminopurine File

Tan, Ying , You, Changjun , Park, Jiyeong , Kim, Hyun Suk , Guo, Su , Scharer, Orlando D. , Wang, Yinsheng

Article Issue Date2022-06 View7
Active DNA damage eviction by HLTF stimulates nucleotide excision repair File

van Toorn, Marvin , Turkyilmaz, Yasemin , Han, Sueji , Zhou, Di , Kim, Hyun-Suk , Salas-Armenteros, Irene , Kim, Mihyun , Akita, Masaki , Wienholz, Franziska , Raams, Anja , et al

Article Issue Date2022-04 View15
A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation File

Aloisi, Claudia M. N. , Escher, Nora A. , Kim, Hyun Suk , Geisen, Susanne M. , Fontana, Gabriele A. , Yeo, Jung-Eun , Scharer, Orlando D. , Sturla, Shana J.

Article Issue Date2022-02 View13
Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes File File

Apelt, Katja , Lans, Hannes , Scharer, Orlando D. , Luijsterburg, Martijn S.

Article Issue Date2021-12 View14
PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations File File

von Werdt, Alexander , Brandt, Laura , Scharer, Orlando D. , Rubin, Mark A.

Article Issue Date2021-10 View10
New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Cross-Links and Their Use to Study Lesion Bypass by DNA Polymerases File

Cheun, Young K. , Groehler, Arnold S. , Schaerer, Orlando D.

Article Issue Date2021-07 View17
ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients File

Apelt, Katja , White, Susan M. , Kim, Hyun Suk , Yeo, Jung-Eun , Kragten, Angela , Wondergem, Annelotte P. , Rooimans, Martin A. , Gonzalez-Prieto, Roman , Wiegant, Wouter W. , Lunke, Sebastian , et al

Article Issue Date2021-03 View13
The complexity and regulation of repair of alkylation damage to nucleic acids File

Tsao, Ning , Scharer, Orlando D. , Mosammaparast, Nima

Article Issue Date2021-03 View14
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair File File

Tsutakawa, Susan E. , Tsai, Chi-Lin , Yan, Chunli , Bralic, Amer , Chazin, Walter J. , Hamdan, Samir M. , Scharer, Orlando D. , Ivanov, Ivaylo , Tainer, John A.

Article Issue Date2020-12 View16
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks File File

Rageul, Julie , Park, Jennifer J. , Zeng, Ping Ping , Lee, Eun-A , Yang, Jihyeon , Hwang, Sunyoung , Lo, Natalie , Weinheimer, Alexandra S. , Scharer, Orlando D. , Yeo, Jung-Eun , et al

Article Issue Date2020-10 View14
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