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Scharer, Orlando D. (ScharerDavid Orlando)

Department
School of Life Sciences(생명과학부)
Research Interests
DNA Damage and Repair and its Relationship to Cancer Biology and Therapy, Chemical, Molecular and Cell Biology
Lab
Website
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2019-08Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23BCheon, Na Young; Kim, Hyun-Suk; Yeo, Jung-Eun, et alARTICLE54 Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B
2019-08MiR223-3p promotes synthetic lethality in BRCA1-deficient cancersSrinivasan, Gayathri; Williamson, Elizabeth A.; Kong, Kimi, et alARTICLE52 MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers
2018-11Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repairMu, Hong; Geacintov, Nicholas E.; Broyde, Suse, et alARTICLE117 Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair
2018-04Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nucleaseJin, Hyeonseok; Roy, Upasana; Lee, Gwangrog, et alARTICLE167 Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease
2017-11FANCI and FANCD2 have common as well as independent functions during the cellular replication stress responseThompson, Elizabeth L.; Yeo, Jung E.; Lee, Eun-A, et alARTICLE263 FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response
2017-10Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair PathwayKato, Niyo; Kawasoe, Yoshitaka; Williams, Hannah, et alARTICLE250 Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
2017-07ERCC1-XPF endonuclease-positioned to cutScharer, Orlando D.ARTICLE263 ERCC1-XPF endonuclease-positioned to cut
2017-05Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repairBeagan, Kelly; Armstrong, Robin L.; Witsell, Alice, et alARTICLE253 Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair
2017-01Preparation of Stable Nitrogen Mustard DNA Interstrand Cross-Link Analogs for Biochemical and Cell Biological StudiesCastano, Alejandra; Roy, Upsana; Scharer, Orlando D.ARTICLE146 Preparation of Stable Nitrogen Mustard DNA Interstrand Cross-Link Analogs for Biochemical and Cell Biological Studies
2016-11Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis PolymerasesWickramaratne, Susith; Ji, Shaofei; Mukherjee, Shivam, et alARTICLE212 Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases
2016-09The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase etaRoy, Upasana; Mukherjee, Shivam; Sharma, Anjali, et alARTICLE290 The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase eta
2016-08Involvement of translesion synthesis DNA polymerases in DNA interstrand crosslink repairRoy, Upasana; Scharer, Orlando D.ARTICLE233 Involvement of translesion synthesis DNA polymerases in DNA interstrand crosslink repair
2015-09FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in VitroPizzolato, Julia; Mukherjee, Shivam; Schaerer, Orlando D., et alARTICLE228 FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in Vitro
2014-06Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursorsMukherjee, Shivam; Guainazzi, Angelo; Scharer, Orlando D.ARTICLE345 Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors
2014-05Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink RepairHodskinson, Michael R. G.; Silhan, Jan; Crossan, Gerry P., et alARTICLE296 Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
2014-02FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV IrradiationGuillemette, Shawna; Branagan, Amy; Peng, Min, et alARTICLE223 FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation
2013-10Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link RepairClauson, Cheryl; Scharer, Orlando D.; Niedernhofer, LauraARTICLE254 Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair
2013-10Nucleotide Excision Repair in EukaryotesScharer, Orlando D.ARTICLE160 Nucleotide Excision Repair in Eukaryotes
2013-09Synthesis of Sequence-Specific DNA-Protein Conjugates via a Reductive Amination StrategyWickramaratne, Susith; Mukherjee, Shivam; Villalta, Peter W., et alARTICLE183 Synthesis of Sequence-Specific DNA-Protein Conjugates via a Reductive Amination Strategy
2013-05Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi AnemiaBogliolo, Massimo; Schuster, Beatrice; Stoepker, Chantal, et alARTICLE173 Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia

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