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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis

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Title
Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis
Author
Gwack, YOUSANGHwang, SEUNGMINByun, HYEWONLim, ChunghunKim, JIN WOOChoi, EUI-JUChoe, JOONHO
Keywords
COACTIVATOR CBP; PROTEIN; P53; IDENTIFICATION; TRANSACTIVATOR; REACTIVATION; ACTIVATION; EXPRESSION; P300; TAX
Issue Date
2001-07
Publisher
AMER SOC MICROBIOLOGY
Citation
JOURNAL OF VIROLOGY, v.75, no.13, pp.6245 - 6248
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here we show that ORF50 represses transcriptional activity of p53 and p53-induced apoptosis through interaction with CREB binding. protein (CBP). This inhibitory effect of ORF50 on the transcriptional activity of p53 was relieved by the addition of CBP. ORF50 mutants, which are defective in interaction with CBP, lost the inhibitory effects on p53. Our data provide a framework for delineating the regulatory mechanisms used by KSHV to modulate cellular transcription and the cell cycle.
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DOI
10.1128/JVI.75.13.6245-6248.2001
ISSN
0022-538X
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BME_Journal Papers
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