There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 6248 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 6245 | - |
dc.citation.title | JOURNAL OF VIROLOGY | - |
dc.citation.volume | 75 | - |
dc.contributor.author | Gwack, YOUSANG | - |
dc.contributor.author | Hwang, SEUNGMIN | - |
dc.contributor.author | Byun, HYEWON | - |
dc.contributor.author | Lim, Chunghun | - |
dc.contributor.author | Kim, JIN WOO | - |
dc.contributor.author | Choi, EUI-JU | - |
dc.contributor.author | Choe, JOONHO | - |
dc.date.accessioned | 2023-12-22T11:43:33Z | - |
dc.date.available | 2023-12-22T11:43:33Z | - |
dc.date.created | 2015-01-06 | - |
dc.date.issued | 2001-07 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here we show that ORF50 represses transcriptional activity of p53 and p53-induced apoptosis through interaction with CREB binding. protein (CBP). This inhibitory effect of ORF50 on the transcriptional activity of p53 was relieved by the addition of CBP. ORF50 mutants, which are defective in interaction with CBP, lost the inhibitory effects on p53. Our data provide a framework for delineating the regulatory mechanisms used by KSHV to modulate cellular transcription and the cell cycle. | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIROLOGY, v.75, no.13, pp.6245 - 6248 | - |
dc.identifier.doi | 10.1128/JVI.75.13.6245-6248.2001 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.scopusid | 2-s2.0-0034990504 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9899 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034990504 | - |
dc.identifier.wosid | 000169175400058 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.title | Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.