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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions

Cited 14 times inthomson ciCited 20 times inthomson ci
Title
The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions
Author
Lee, DaeyoupLim, ChunghunSeo, TaegunKwon, HyockmanMin, HyesuChoe, Joonho
Keywords
RETINOBLASTOMA TUMOR-SUPPRESSOR;  MAMMALIAN SWI/SNF COMPLEXES;  CELL-CYCLE ARREST;  C-FOS GENE;  TYPE-16 E7;  HISTONE ACETYLATION;  SACCHAROMYCES-CEREVISIAE;  TRANSFORMING ACTIVITY;  MUTATIONAL ANALYSIS;  HUMAN KERATINOCYTES
Issue Date
2002-12
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.277, no.50, pp.48842 - 48848
Abstract
BRG-1, a component of the human SWI/SNF complex, either activates or represses cellular promoters by modulating chromatin structure via the formation of a multiple polypeptide complex. Human papillomavirus E7 binds and destabilizes pRb, resulting in the blockage of G(1) arrest in the cell cycle. We show here that the high-risk human papillomavirus E7 protein group binds BRG-1 and modulates repression of the c-fos promoter mediated by this protein. In addition, both wild-type and Rb binding-defective E7 proteins abolish flat cell formation by BRG-1 in SW13 cells, whereas E7 COOH-terminal mutants do not affect this process. BRG-1-triggered repression of the c-fos promoter is sensitive to trichostatin A. We further establish that BRG-1 contains an activation domain and a trichostatin A-sensitive repression domain. These results collectively suggest that the viral oncogene E7 targets both pRb and BRG-1 via protein-protein interactions, resulting in the deregulation of host cell cycle control.
URI
https://scholarworks.unist.ac.kr/handle/201301/9842
DOI
10.1074/jbc.M203583200
ISSN
0021-9258
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