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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 48848 | - |
dc.citation.number | 50 | - |
dc.citation.startPage | 48842 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 277 | - |
dc.contributor.author | Lee, Daeyoup | - |
dc.contributor.author | Lim, Chunghun | - |
dc.contributor.author | Seo, Taegun | - |
dc.contributor.author | Kwon, Hyockman | - |
dc.contributor.author | Min, Hyesu | - |
dc.contributor.author | Choe, Joonho | - |
dc.date.accessioned | 2023-12-22T11:36:24Z | - |
dc.date.available | 2023-12-22T11:36:24Z | - |
dc.date.created | 2015-01-06 | - |
dc.date.issued | 2002-12 | - |
dc.description.abstract | BRG-1, a component of the human SWI/SNF complex, either activates or represses cellular promoters by modulating chromatin structure via the formation of a multiple polypeptide complex. Human papillomavirus E7 binds and destabilizes pRb, resulting in the blockage of G(1) arrest in the cell cycle. We show here that the high-risk human papillomavirus E7 protein group binds BRG-1 and modulates repression of the c-fos promoter mediated by this protein. In addition, both wild-type and Rb binding-defective E7 proteins abolish flat cell formation by BRG-1 in SW13 cells, whereas E7 COOH-terminal mutants do not affect this process. BRG-1-triggered repression of the c-fos promoter is sensitive to trichostatin A. We further establish that BRG-1 contains an activation domain and a trichostatin A-sensitive repression domain. These results collectively suggest that the viral oncogene E7 targets both pRb and BRG-1 via protein-protein interactions, resulting in the deregulation of host cell cycle control. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.277, no.50, pp.48842 - 48848 | - |
dc.identifier.doi | 10.1074/jbc.M203583200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-0037073682 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9842 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037073682 | - |
dc.identifier.wosid | 000179789600113 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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