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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions

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dc.contributor.author Lee, Daeyoup ko
dc.contributor.author Lim, Chunghun ko
dc.contributor.author Seo, Taegun ko
dc.contributor.author Kwon, Hyockman ko
dc.contributor.author Min, Hyesu ko
dc.contributor.author Choe, Joonho ko
dc.date.available 2015-01-06T00:57:13Z -
dc.date.created 2015-01-06 ko
dc.date.issued 2002-12 ko
dc.identifier.citation JOURNAL OF BIOLOGICAL CHEMISTRY, v.277, no.50, pp.48842 - 48848 ko
dc.identifier.issn 0021-9258 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/9842 -
dc.description.abstract BRG-1, a component of the human SWI/SNF complex, either activates or represses cellular promoters by modulating chromatin structure via the formation of a multiple polypeptide complex. Human papillomavirus E7 binds and destabilizes pRb, resulting in the blockage of G(1) arrest in the cell cycle. We show here that the high-risk human papillomavirus E7 protein group binds BRG-1 and modulates repression of the c-fos promoter mediated by this protein. In addition, both wild-type and Rb binding-defective E7 proteins abolish flat cell formation by BRG-1 in SW13 cells, whereas E7 COOH-terminal mutants do not affect this process. BRG-1-triggered repression of the c-fos promoter is sensitive to trichostatin A. We further establish that BRG-1 contains an activation domain and a trichostatin A-sensitive repression domain. These results collectively suggest that the viral oncogene E7 targets both pRb and BRG-1 via protein-protein interactions, resulting in the deregulation of host cell cycle control. ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC ko
dc.title The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0037073682 ko
dc.identifier.wosid 000179789600113 ko
dc.type.rims ART ko
dc.description.wostc 14 *
dc.description.scopustc 20 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1074/jbc.M203583200 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037073682 ko
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