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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus

Cited 13 times inthomson ciCited 14 times inthomson ci
Title
Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus
Author
Lim, ChunghunChoi, ChangtaekChoe, Joonho
Keywords
EPSTEIN-BARR-VIRUS; HUMAN-CELLS; GENE-EXPRESSION; VIRAL GENOME; E2 PROTEIN; TRANSIENT REPLICATION; EPISOMAL MAINTENANCE; PLASMID MAINTENANCE; STABLE REPLICATION; HOST CHROMOSOMES
Issue Date
2004-07
Publisher
AMER SOC MICROBIOLOGY
Citation
JOURNAL OF VIROLOGY, v.78, no.13, pp.7248 - 7256
Abstract
Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the persistence of the viral genome during latent infection. It has been suggested that LANA1 tethers the viral genome to the host chromosome and also participates actively in DNA replication from the terminal repeat of KSHV. Here we show by mutational analysis that the mitotic chromosome-binding activity of LANA1 is tightly coupled to its replication activity. Thus, KSHV appears to have evolved a unique tactic for its stable maintenance.
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DOI
10.1128/JVI.78.13.7248-7356.2004
ISSN
0022-538X
Appears in Collections:
BME_Journal Papers
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