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Lee, Jiseok
Synthesis of Polymeric Optical Nano/Micro-architectures lab
Research Interests
  • Optofluidic photolithography
  • Nanoparticle Synthesis
  • Conjugated polymer design and Synthesis
  • Flow lithography
  • 3d printing

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Polydiacetylene liposome arrays for selective potassium detection

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Title
Polydiacetylene liposome arrays for selective potassium detection
Author
Lee, JiseokKim, Hyong-JunKim, Jinsang
Issue Date
2008-04
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.130, no.15, pp.5010 - 5011
Abstract
Potassium is an important cation in biology, and quantitative detection of the extracellular potassium level is important. However, selective detection of extracellular physiological potassium is a challenging task due to the presence of sodium in a much higher concentration. In this contribution, we describe the development of practical polydiacetylene (PDA) liposome-based microarrays to selectively detect potassium even in the presence of sodium. We utilize the fact that the G-rich ssDNA can fold into a G-quadruplex via intramolecular hydrogen bonding by wrapping around a potassium ion exclusively. We rationally design the PDA liposome in such a way that the G-rich ssDNA probes are presented densely at the liposome surface and form bulky quadruplexes upon binding with K+. The resulting bulky quadruplexes are sterically hindered and repulse each other and impose mechanical stress on the PDA backbone, resulting in the conformational change of the ene-yne backbone of the PDA. As a result, polydiacetylene liposomes turn into the emissive red phase from the nonfluorescent blue phase.
URI
https://scholarworks.unist.ac.kr/handle/201301/9605
DOI
10.1021/ja709996c
ISSN
0002-7863
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