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DC Field | Value | Language |
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dc.citation.endPage | 5011 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5010 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 130 | - |
dc.contributor.author | Lee, Jiseok | - |
dc.contributor.author | Kim, Hyong-Jun | - |
dc.contributor.author | Kim, Jinsang | - |
dc.date.accessioned | 2023-12-22T08:41:38Z | - |
dc.date.available | 2023-12-22T08:41:38Z | - |
dc.date.created | 2014-12-22 | - |
dc.date.issued | 2008-04 | - |
dc.description.abstract | Potassium is an important cation in biology, and quantitative detection of the extracellular potassium level is important. However, selective detection of extracellular physiological potassium is a challenging task due to the presence of sodium in a much higher concentration. In this contribution, we describe the development of practical polydiacetylene (PDA) liposome-based microarrays to selectively detect potassium even in the presence of sodium. We utilize the fact that the G-rich ssDNA can fold into a G-quadruplex via intramolecular hydrogen bonding by wrapping around a potassium ion exclusively. We rationally design the PDA liposome in such a way that the G-rich ssDNA probes are presented densely at the liposome surface and form bulky quadruplexes upon binding with K+. The resulting bulky quadruplexes are sterically hindered and repulse each other and impose mechanical stress on the PDA backbone, resulting in the conformational change of the ene-yne backbone of the PDA. As a result, polydiacetylene liposomes turn into the emissive red phase from the nonfluorescent blue phase. | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.130, no.15, pp.5010 - 5011 | - |
dc.identifier.doi | 10.1021/ja709996c | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9605 | - |
dc.identifier.wosid | 000254933000005 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Polydiacetylene liposome arrays for selective potassium detection | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CONJUGATED POLYMERS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | WATER | - |
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