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Lee, Jiseok
Novel Optofluidic Materials Synthesis Lab
Research Interests
  • Optofluidic photolithography
  • Nanoparticle Synthesis
  • Conjugated polymer design and Synthesis
  • Flow lithography
  • 3d printing

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Colorimetric Detection of Warfare Gases by Polydiacetylenes Toward Equipment-Free Detection

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Title
Colorimetric Detection of Warfare Gases by Polydiacetylenes Toward Equipment-Free Detection
Author
Lee, JiseokSeo, SungbaekKim, Jinsang
Issue Date
2012-04
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED FUNCTIONAL MATERIALS, v.22, no.8, pp.1632 - 1638
Abstract
Rationally designed polydiacetylene (PDA) molecules have been developed for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate (OP) nerve agents, a mass destruction weapon. Oxime (OX) functionality was incorporated into diacetylene molecules to utilize its strong affinity toward organophosphates. The diacetylene molecules having an OX functional group (OX-PDA) were self-assembled to form PDA liposomes in an aqueous solution. Upon exposure to organophosphate nerve agent simulants, OX at the OX-PDA liposome surface interacts with nerve agent simulants, which results in intraliposomal repulsive stress due to steric repulsion between OP-occupied OX units at the liposome surface as well as interliposomal aggregation induced by increased hydrophobicity of the liposome surface via OP-OX complex formation. The resulting intra- and interliposomal stress causes disturbance of the conjugated backbone of OX-PDA, producing color change as a label-free and sensitive sensory signal. The effects of molecular structure on selectivity and sensitivity of OX-PDA liposome solution, OX-PDA liposome-embedded agarose gels, and OX-PDA liposome-coated cellulose acetate membranes were systematically investigated. The optimized OX-PDA liposome in the solid state showed selective and rapid optical transition upon exposure down to 160 ppb of diisopropylfluorophosphate (DFP), a nerve agent simulant. The results provide an insightful molecular design principle of PDA-based colorimetric sensor and suggest portable sensory patches for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate nerve agents.
URI
https://scholarworks.unist.ac.kr/handle/201301/9595
DOI
10.1002/adfm.201102486
ISSN
1616-301X
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