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Lee, Jiseok
Novel Optofluidic Materials Synthesis Lab
Research Interests
  • Optofluidic photolithography
  • Nanoparticle Synthesis
  • Conjugated polymer design and Synthesis
  • Flow lithography
  • 3d printing

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Polydiacetylene Liposome Microarray Toward Influenza A Virus Detection: Effect of Target Size on Turn-On Signaling

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Title
Polydiacetylene Liposome Microarray Toward Influenza A Virus Detection: Effect of Target Size on Turn-On Signaling
Author
Seo, SungbaekLee, JiseokChoi, Eun-JinKim, Eun-JuSong, Jae-YoungKim, Jinsang
Keywords
conjugated polymers; influenza A virus; liposome microarray; sensors; target size
Issue Date
2013-05
Publisher
WILEY-V C H VERLAG GMBH
Citation
MACROMOLECULAR RAPID COMMUNICATIONS, v.34, no.9, pp.743 - 748
Abstract
Target size effect on the sensory signaling intensity of polydiacetylene (PDA) liposome microarrays was systematically investigated. Influenza A virus M1 peptide and M1 antibody were selected as a probetarget pair. While red fluorescence from the PDA liposome microarrays was observed when the larger M1 antibody was used as a target, when the same M1 antibody was used as a probe to detect the smaller M1 peptide sensory signal did not appear. The results reveal that the intensity of the PDA sensory signal is mainly related to the steric repulsion between probetarget complexes not the strength of the probetarget binding force. Based on this finding, we devised a PDA sensory system that directly detects influenza A whole virus as a larger target, and confirmed the target size effect on the signaling efficiency of PDA.
URI
https://scholarworks.unist.ac.kr/handle/201301/9587
DOI
10.1002/marc.201200819
ISSN
1022-1336
Appears in Collections:
ECHE_Journal Papers
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