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Choi, Jang Hyun
Lab of Diabetes and Metabolism (LDM)
Research Interests
  • Diabetes, Metabolic Disorders, PPARg, Gene Regulation, Anti-Diabetic Drug

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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

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Title
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
Author
Wu, JunBostrom, PontusSparks, Lauren M.Ye, LiChoi, Jang HyunGiang, An-HoaKhandekar, MelinVirtanen, Kirsi A.Nuutila, PirjoSchaart, GertHuang, KexinTu, HuaLichtenbelt, Wouter D. van MarkenHoeks, JorisEnerbaeck, SvenSchrauwen, PatrickSpiegelman, Bruce M.
Issue Date
2012-07
Publisher
CELL PRESS
Citation
CELL, v.150, no.2, pp.366 - 376
Abstract
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential.
URI
https://scholarworks.unist.ac.kr/handle/201301/9464
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864287504
DOI
10.1016/j.cell.2012.05.016
ISSN
0092-8674
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BIO_Journal Papers
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