Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
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- Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
- Lee, YH; Bae, SS; Seo, Jeong Kon; Choi, I; Ryu, SH; Suh, Pann-Ghill
- Issue Date
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- MOLECULES AND CELLS, v.10, no.4, pp.469 - 474
- Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.
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