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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells

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Title
Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
Author
Lee, YHBae, SSSeo, Jeong KonChoi, IRyu, SHSuh, Pann-Ghill
Issue Date
2000-08
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v.10, no.4, pp.469 - 474
Abstract
Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.
URI
https://scholarworks.unist.ac.kr/handle/201301/9096
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034738927
ISSN
1016-8478
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BIO_Journal Papers
UCRF_Journal Papers
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