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- Suh, Pann-Ghill
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| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 474 | - |
| dc.citation.number | 4 | - |
| dc.citation.startPage | 469 | - |
| dc.citation.title | MOLECULES AND CELLS | - |
| dc.citation.volume | 10 | - |
| dc.contributor.author | Lee, YH | - |
| dc.contributor.author | Bae, SS | - |
| dc.contributor.author | Seo, Jeong Kon | - |
| dc.contributor.author | Choi, I | - |
| dc.contributor.author | Ryu, SH | - |
| dc.contributor.author | Suh, Pann-Ghill | - |
| dc.date.accessioned | 2023-12-22T12:07:06Z | - |
| dc.date.available | 2023-12-22T12:07:06Z | - |
| dc.date.created | 2014-11-19 | - |
| dc.date.issued | 2000-08 | - |
| dc.description.abstract | Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation. | - |
| dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.10, no.4, pp.469 - 474 | - |
| dc.identifier.issn | 1016-8478 | - |
| dc.identifier.scopusid | 2-s2.0-0034738927 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9096 | - |
| dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034738927 | - |
| dc.identifier.wosid | 000088939500017 | - |
| dc.language | 영어 | - |
| dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
| dc.title | Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells | - |
| dc.type | Article | - |
| dc.description.journalRegisteredClass | scopus | - |
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