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- Nam, Dougu
- Bioinformatics Lab.
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Dynamic and reversible transcriptomic age shifts induced by COVID-19 in Korean whole blood
- Author(s)
- An, Kyungwhan, Kwon, Yoonsung, Bhak, Jihun, Ryu, Hyojung, Jeon, Sungwon, Nam, Dougu, Bhak, Jong
- Issued Date
- 2025-06
- Citation
- Aging, v.17, no.6, pp.1484 - 1510
- Abstract
- We developed the first genome-wide transcriptomic clock specific to Korean ethnicity to predict chronological age using whole blood samples from 440 healthy individuals. Our analysis revealed profound age acceleration – up to 21.31 years – during homeostatic disruption in COVID-19 patients, which reverted to baseline upon recovery. These findings highlight the ability of the blood transcriptome to dynamically track reversible changes in age-associated inflammatory responses during infections. Our study underscores the potential of anti-aging interventions in managing infectious diseases. © 2025 An et al.
- Publisher
- Impact Journals LLC
- ISSN
- 1945-4589
- Keyword (Author)
- RNA-seq, whole blood, aging clock, anti-aging, COVID-19
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