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Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Inherent Charge-Shifting Polyelectrolyte Multilayer Blends: A Facile Route for Tunable Protein Release from Surfaces

Cited 16 times inthomson ciCited 12 times inthomson ci
Title
Inherent Charge-Shifting Polyelectrolyte Multilayer Blends: A Facile Route for Tunable Protein Release from Surfaces
Author
Hong, JinkeeKim, Byeong-SuChar, KookheonHammond, Paula T.
Keywords
Amino esters; Antigen proteins; Aqueous processing; Biologic drugs; Biomedical surfaces; Controlled release; Deposition solution; Different mechanisms; Drug coatings; High activity; Layer by layer deposition; Orders of magnitude; Ovalbumins; Physiological pH; Poly-L-lysine; Polyamines; Polyelectrolyte multilayer; Polyions; Positively charged; Protein release; Sequential delivery; Time-scales; Tunable properties
Issue Date
2011-08
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.12, no.8, pp.2975 - 2981
Abstract
Recent research has highlighted degradable multilayer films that enable the programmed release of different therapeutics. Multilayers constructed by the layer-by-layer (LbL) deposition that can undergo disassembly have been demonstrated to be of considerable interest, particularly for biomedical surface coatings due to their versatility and mild aqueous processing conditions, enabling the inclusion of biologic drugs with high activity. In this study, we examine the controlled release of a protein using a different mechanism for film disassembly, the gradual dissociation of film interactions under release conditions. Poly(beta-amino ester)s and poly(L-lysine) (PLL) were used as the positively charged multilayer components coassembled with a model negatively charged antigen protein, ovalbumin (Ova). The release of the protein from these multilayer films is dominated by the slow shift in the charge of components under physiological pH conditions rather than by hydrolytic degradative release. The time scale of release can be varied over almost 2 orders of magnitude by varying the ratio of the two polyamines in the deposition solution. The highly versatile and tunable properties of these films form a basis for designing controlled and sequential delivery of drug coatings using a variety of polyions.
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DOI
10.1021/bm200566k
ISSN
1525-7797
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PHY_Journal Papers
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