Related Researcher

Author's Photo

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications


Inherent Charge-Shifting Polyelectrolyte Multilayer Blends: A Facile Route for Tunable Protein Release from Surfaces

DC Field Value Language Hong, Jinkee ko Kim, Byeong-Su ko Char, Kookheon ko Hammond, Paula T. ko 2014-11-17T08:07:43Z - 2014-11-14 ko 2011-08 -
dc.identifier.citation BIOMACROMOLECULES, v.12, no.8, pp.2975 - 2981 ko
dc.identifier.issn 1525-7797 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Recent research has highlighted degradable multilayer films that enable the programmed release of different therapeutics. Multilayers constructed by the layer-by-layer (LbL) deposition that can undergo disassembly have been demonstrated to be of considerable interest, particularly for biomedical surface coatings due to their versatility and mild aqueous processing conditions, enabling the inclusion of biologic drugs with high activity. In this study, we examine the controlled release of a protein using a different mechanism for film disassembly, the gradual dissociation of film interactions under release conditions. Poly(beta-amino ester)s and poly(L-lysine) (PLL) were used as the positively charged multilayer components coassembled with a model negatively charged antigen protein, ovalbumin (Ova). The release of the protein from these multilayer films is dominated by the slow shift in the charge of components under physiological pH conditions rather than by hydrolytic degradative release. The time scale of release can be varied over almost 2 orders of magnitude by varying the ratio of the two polyamines in the deposition solution. The highly versatile and tunable properties of these films form a basis for designing controlled and sequential delivery of drug coatings using a variety of polyions. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher AMER CHEMICAL SOC ko
dc.subject Amino esters ko
dc.subject Antigen proteins ko
dc.subject Aqueous processing ko
dc.subject Biologic drugs ko
dc.subject Biomedical surfaces ko
dc.subject Controlled release ko
dc.subject Deposition solution ko
dc.subject Different mechanisms ko
dc.subject Drug coatings ko
dc.subject High activity ko
dc.subject Layer by layer deposition ko
dc.subject Orders of magnitude ko
dc.subject Ovalbumins ko
dc.subject Physiological pH ko
dc.subject Poly-L-lysine ko
dc.subject Polyamines ko
dc.subject Polyelectrolyte multilayer ko
dc.subject Polyions ko
dc.subject Positively charged ko
dc.subject Protein release ko
dc.subject Sequential delivery ko
dc.subject Time-scales ko
dc.subject Tunable properties ko
dc.title Inherent Charge-Shifting Polyelectrolyte Multilayer Blends: A Facile Route for Tunable Protein Release from Surfaces ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-80051529280 ko
dc.identifier.wosid 000293488200015 ko
dc.type.rims ART ko
dc.description.wostc 16 *
dc.description.scopustc 12 * 2015-05-06 * 2014-11-14 *
dc.identifier.doi 10.1021/bm200566k ko
Appears in Collections:
PHY_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record


  • mendeley


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.