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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors

Cited 89 times inthomson ciCited 86 times inthomson ci
Title
Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors
Author
Hilderbrand, SALim, Mi HeeLippard, SJ
Keywords
LONG-TERM POTENTIATION; BIOLOGICAL-SYSTEMS; CRYSTAL-STRUCTURES; NITROGEN MONOXIDE; NOBEL LECTURE; NO; LIGANDS; REACTIVITY; BIOSENSORS; COMPLEXES
Issue Date
2004-04
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.126, no.15, pp.4972 - 4978
Abstract
We report the synthesis and characterization of dirhodium tetracarboxylate complexes [Rh2(μ-O2CR)4(L)2], with R = Me and L = dansyl-imidazole (Ds-im) or dansyl-piperazine (Ds-pip). The fluorophores coordinate to the axial sites of the dirhodium core through the imidazole or piperazine N-atom and emit only weakly when excited at 365 or 345 nm for the Ds-im and Ds-pip complexes, respectively. These fluorophore-containing complexes were investigated for their ability to elicit a fluorescence response in the presence of NO. An immediate increase in fluorescence emission of greater than 15-fold occurs when NO is admitted to solutions containing [Rh2(μ-O2CMe)4] and Ds-pip or Ds-im. In both systems, the fluorescence response, which arises by NO-induced displacement of the axially coordinated fluorophore, is reversible with a sensitivity of ∼4 μM. The related dinitrosyl complexes [Rh 2(μ-O2CR)4(NO)2], where R = Me, Et, or n-Pr, were prepared, structurally characterized, and found to be air-stable, losing NO upon standing in solution. Sequestration of a methylene chloride solution of the Ds-pip complex from aqueous media by a NO-permeable membrane allows for fluorescence detection of NO for potential applications in biological fluids.
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DOI
10.1021/ja038471j
ISSN
0002-7863
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PHY_Journal Papers
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