dc.citation.endPage |
4978 |
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dc.citation.number |
15 |
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dc.citation.startPage |
4972 |
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dc.citation.title |
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY |
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dc.citation.volume |
126 |
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dc.contributor.author |
Hilderbrand, SA |
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dc.contributor.author |
Lim, Mi Hee |
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dc.contributor.author |
Lippard, SJ |
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dc.date.accessioned |
2023-12-22T11:06:40Z |
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dc.date.available |
2023-12-22T11:06:40Z |
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dc.date.created |
2014-11-11 |
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dc.date.issued |
2004-04 |
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dc.description.abstract |
We report the synthesis and characterization of dirhodium tetracarboxylate complexes [Rh2(μ-O2CR)4(L)2], with R = Me and L = dansyl-imidazole (Ds-im) or dansyl-piperazine (Ds-pip). The fluorophores coordinate to the axial sites of the dirhodium core through the imidazole or piperazine N-atom and emit only weakly when excited at 365 or 345 nm for the Ds-im and Ds-pip complexes, respectively. These fluorophore-containing complexes were investigated for their ability to elicit a fluorescence response in the presence of NO. An immediate increase in fluorescence emission of greater than 15-fold occurs when NO is admitted to solutions containing [Rh2(μ-O2CMe)4] and Ds-pip or Ds-im. In both systems, the fluorescence response, which arises by NO-induced displacement of the axially coordinated fluorophore, is reversible with a sensitivity of ∼4 μM. The related dinitrosyl complexes [Rh 2(μ-O2CR)4(NO)2], where R = Me, Et, or n-Pr, were prepared, structurally characterized, and found to be air-stable, losing NO upon standing in solution. Sequestration of a methylene chloride solution of the Ds-pip complex from aqueous media by a NO-permeable membrane allows for fluorescence detection of NO for potential applications in biological fluids. |
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dc.identifier.bibliographicCitation |
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.126, no.15, pp.4972 - 4978 |
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dc.identifier.doi |
10.1021/ja038471j |
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dc.identifier.issn |
0002-7863 |
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dc.identifier.scopusid |
2-s2.0-1842841021 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/8659 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1842841021 |
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dc.identifier.wosid |
000220849900047 |
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dc.language |
영어 |
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dc.publisher |
AMER CHEMICAL SOC |
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dc.title |
Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
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