Fluorescence-based nitric oxide detection by ruthenium porphyrin fluorophore complexes
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- Fluorescence-based nitric oxide detection by ruthenium porphyrin fluorophore complexes
- Lim, Mi Hee; Lippard, SJ
- SOLUBLE GUANYLATE-CYCLASE; RELAXING FACTOR; NOBEL LECTURE; NO; SPECTROSCOPY; LIGAND; METALLOPORPHYRINS; REACTIVITY; INDICATORS; MECHANISM
- Issue Date
- AMER CHEMICAL SOC
- INORGANIC CHEMISTRY, v.43, no.20, pp.6366 - 6370
- The ruthenium(II) porphyrin fluorophore complexes [Ru(TPP)(CO)(Ds-R)] (TPP = tetraphenylporphinato dianion; Ds = dansyl; R = imidazole (im), 1, or thiomorpholine (tm), 2) were synthesized and investigated for their ability to detect nitric oxide (NO) based on fluorescence. The X-ray crystal structures of 1 and 2 were determined. The Ds-im or Ds-tm ligand coordinates to an axial site of the ruthenium(II) center through a nitrogen or sulfur atom, respectively. Both exhibit quenched fluorescence when excited at 368 or 345 nm. Displacement of the metal-coordinated fluorophore by NO restores fluorescence within minutes. These observations demonstrate fluorescence-based NO detection using ruthenium porphyrin fluorophore conjugates.
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