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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes

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Title
Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes
Author
Jun, Dong-JaeNa, Kyung-YoonKim, WanilKwak, DongohKwon, Eun-JeongYoon, Jong HyukYea, KyungmooLee, HyeongjiKim, JaeyoonSuh, Pann-GhillRyu, Sung HoKim, Kyong-Tai
Issue Date
2010-04
Publisher
BIOSCIENTIFICA LTD
Citation
JOURNAL OF MOLECULAR ENDOCRINOLOGY, v.44, no.4, pp.225 - 236
Abstract
Interleukin 6 (IL6) is a pleiotropic cytokine that not only affects the immune system, but also plays an active role in many physiological events in various organs. Notably, 35% of systemic IL6 originates from adipose tissues under noninflammatory conditions. Here, we describe a previously unknown function of melanocortins in regulating Il6 gene expression and production in 3T3-L1 adipocytes through membrane receptors which are called melanocortin receptors (MCRs). Of the five MCRs that have been cloned, MC2R and MC5R are expressed during adipocyte differentiation. α-Melanocyte-stimulating hormone (α-MSH) or ACTH treatment of 3T3-L1 adipocytes induces Il6 gene expression and production in a time- and concentration-dependent manner via various signaling pathways including the protein kinase A, p38 mitogen-activated protein kinase, cJun N-terminal kinase, and IκB kinase pathways. Specific inhibition of MC2R and MC5R expression with short interfering Mc2r and Mc5r RNAs significantly attenuated the α-MSH-induced increase of intracellular cAMP and both the level of Il6 mRNA and secretion of IL6 in 3T3-L1 adipocytes. Finally, when injected into mouse tail vein, α-MSH dramatically increased the Il6 transcript levels in epididymal fat pads. These results suggest that α-MSH in addition to ACTH may function as a regulator of inflammation by regulating cytokine production.
URI
https://scholarworks.unist.ac.kr/handle/201301/8430
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77950221237
DOI
10.1677/JME-09-0161
ISSN
0952-5041
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BIO_Journal Papers
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