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DC Field | Value | Language |
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dc.citation.endPage | 236 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 225 | - |
dc.citation.title | JOURNAL OF MOLECULAR ENDOCRINOLOGY | - |
dc.citation.volume | 44 | - |
dc.contributor.author | Jun, Dong-Jae | - |
dc.contributor.author | Na, Kyung-Yoon | - |
dc.contributor.author | Kim, Wanil | - |
dc.contributor.author | Kwak, Dongoh | - |
dc.contributor.author | Kwon, Eun-Jeong | - |
dc.contributor.author | Yoon, Jong Hyuk | - |
dc.contributor.author | Yea, Kyungmoo | - |
dc.contributor.author | Lee, Hyeongji | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.date.accessioned | 2023-12-22T07:10:21Z | - |
dc.date.available | 2023-12-22T07:10:21Z | - |
dc.date.created | 2014-11-07 | - |
dc.date.issued | 2010-04 | - |
dc.description.abstract | Interleukin 6 (IL6) is a pleiotropic cytokine that not only affects the immune system, but also plays an active role in many physiological events in various organs. Notably, 35% of systemic IL6 originates from adipose tissues under noninflammatory conditions. Here, we describe a previously unknown function of melanocortins in regulating Il6 gene expression and production in 3T3-L1 adipocytes through membrane receptors which are called melanocortin receptors (MCRs). Of the five MCRs that have been cloned, MC2R and MC5R are expressed during adipocyte differentiation. α-Melanocyte-stimulating hormone (α-MSH) or ACTH treatment of 3T3-L1 adipocytes induces Il6 gene expression and production in a time- and concentration-dependent manner via various signaling pathways including the protein kinase A, p38 mitogen-activated protein kinase, cJun N-terminal kinase, and IκB kinase pathways. Specific inhibition of MC2R and MC5R expression with short interfering Mc2r and Mc5r RNAs significantly attenuated the α-MSH-induced increase of intracellular cAMP and both the level of Il6 mRNA and secretion of IL6 in 3T3-L1 adipocytes. Finally, when injected into mouse tail vein, α-MSH dramatically increased the Il6 transcript levels in epididymal fat pads. These results suggest that α-MSH in addition to ACTH may function as a regulator of inflammation by regulating cytokine production. | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR ENDOCRINOLOGY, v.44, no.4, pp.225 - 236 | - |
dc.identifier.doi | 10.1677/JME-09-0161 | - |
dc.identifier.issn | 0952-5041 | - |
dc.identifier.scopusid | 2-s2.0-77950221237 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/8430 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77950221237 | - |
dc.identifier.wosid | 000275774600004 | - |
dc.language | 영어 | - |
dc.publisher | BIOSCIENTIFICA LTD | - |
dc.title | Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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