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Development of Biocompatible Quantum Dots using Zwitterionic Copolymer for Biological Application

Author(s)
Yoon, Kicheol
Advisor
Park, Jongnam
Issued Date
2013-11
URI
https://scholarworks.unist.ac.kr/handle/201301/82776 http://unist.dcollection.net/jsp/common/DcLoOrgPer.jsp?sItemId=000001656149
Abstract
In recent years, zwitterionic polymers has been extensively studied because of their unique water-stability and highly efficient non-biofouling property. This work describes a new class of polymeric ligands for quantum Dot (QD), QDs coated short-chain zwitterionic ligand were stabilized against aggregation from proteins. The zwitterionic polymers are synthesized by reversible addition-fragmentation chain transfer-mediated polymerization to control the uniform molecular weight of random copolymer with histidine group for binding QD surface, and (3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide (MPDSAH) group for water solubilization, and primary amine group as binding site for derivatization. Then by carefully handling primary amine of surface, folate-conjugated QDs (QD-FAs) with high photostability are prepared. We demonstrate receptor-mediated conjugation of folic acid functionalized QDs on live cell lines such as Hela cells.
Publisher
Ulsan National Institute of Science and Technology (UNIST)
Degree
Master
Major
Graduate School of UNIST Department Of Chemistry

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