dc.contributor.advisor |
Park, Jongnam |
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dc.contributor.author |
Yoon, Kicheol |
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dc.date.accessioned |
2024-05-27T15:23:12Z |
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dc.date.available |
2024-05-27T15:23:12Z |
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dc.date.issued |
2013-11 |
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dc.description.abstract |
In recent years, zwitterionic polymers has been extensively studied because of their unique water-stability and highly efficient non-biofouling property. This work describes a new class of polymeric ligands for quantum Dot (QD), QDs coated short-chain zwitterionic ligand were stabilized against aggregation from proteins. The zwitterionic polymers are synthesized by reversible addition-fragmentation chain transfer-mediated polymerization to control the uniform molecular weight of random copolymer with histidine group for binding QD surface, and (3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide (MPDSAH) group for water solubilization, and primary amine group as binding site for derivatization. Then by carefully handling primary amine of surface, folate-conjugated QDs (QD-FAs) with high photostability are prepared. We demonstrate receptor-mediated conjugation of folic acid functionalized QDs on live cell lines such as Hela cells. |
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dc.description.degree |
Master |
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dc.description |
Graduate School of UNIST Department Of Chemistry |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/82776 |
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dc.identifier.uri |
http://unist.dcollection.net/jsp/common/DcLoOrgPer.jsp?sItemId=000001656149 |
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dc.language |
eng |
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dc.publisher |
Ulsan National Institute of Science and Technology (UNIST) |
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dc.rights.embargoReleaseDate |
9999-12-31 |
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dc.rights.embargoReleaseTerms |
9999-12-31 |
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dc.title |
Development of Biocompatible Quantum Dots using Zwitterionic Copolymer for Biological Application |
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dc.type |
Thesis |
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