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정웅규

Jung, Woonggyu
Translational Biophotonics Lab.
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Implementation of a portable diffraction phase microscope for digital histopathology

Author(s)
Aimakov, NurbolatMin, EunjungBan, SungbeaLee, SangjinBae, Jung KweonYou, Joon S.Jung, Woonggyu
Issued Date
2024-03
DOI
10.1002/jbio.202300496
URI
https://scholarworks.unist.ac.kr/handle/201301/81662
Citation
JOURNAL OF BIOPHOTONICS, v.17, no.3, pp.e202300496
Abstract
Quantitative phase imaging (QPI) has a significant advantage in histopathology as it helps in differentiating biological tissue structures and cells without the need for staining. To make this capability more accessible, it is crucial to develop compact and portable systems. In this study, we introduce a portable diffraction phase microscopy (DPM) system that allows the acquisition of phase map images from various organs in mice using a low-NA objective lens. Our findings indicate that the cell and tissue structures observed in portable DPM images are similar to those seen in conventional histology microscope images. We confirmed that the developed system's performance is comparable to the benchtop DPM system. Additionally, we investigate the potential utility of digital histopathology by applying deep learning technology to create virtual staining of DPM images.
Publisher
WILEY-V C H VERLAG GMBH
ISSN
1864-063X
Keyword (Author)
diffraction phase microscopyquantitative phase imagingvirtual staining
Keyword
OPTICAL-PROPERTIESTOMOGRAPHYCELLS

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