File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

차채녕

Cha, Chaenyung
Integrative Biomaterials Engineering Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Biodegradable Polymer Crosslinker: Independent Control of Stiffness, Toughness, and Hydrogel Degradation Rate

Author(s)
Cha, ChaenyungKohmon, Richie E.Kong, Hyunjoon
Issued Date
2009-10
DOI
10.1002/adfm.200900865
URI
https://scholarworks.unist.ac.kr/handle/201301/7883
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349680606
Citation
ADVANCED FUNCTIONAL MATERIALS, v.19, no.19, pp.3056 - 3062
Abstract
Hydrogels are being increasingly studied for use in various biomedical applications including drug delivery and tissue engineering. The successful use of a hydrogel in these applications greatly relies on a refined control of the mechanical properties including stiffness, toughness, and the degradation rate. However, it is still challenging to control the hydrogel properties in an independent manner due to the interdependency between hydrogel properties. Here it is hypothesized that a biodegradable polymeric crosslinker would allow for decoupling of the dependency between the properties of various hydrogel materials. This hypothesis is examined using oxidized methacrylic alginate (OMA). The OMA is synthesized by partially oxidizing alginate to generate hydrolytically labile units and conjugating methacrylic groups. It is used to crosslink poly(ethylene glycol) methacrylate and poly(N- hydroxymethyl acrylamide) to form three-dimensional hydrogel systems. OMA significantly improves rigidity and toughness of both hydrogels as compared with a small molecule crosslinker, and also controls the degradation rate of hydrogels depending on the oxidation degree, without altering their initial mechanical properties. The protein-release rate from a hydrogel and subsequent angiogenesis in vivo are thus regulated with the chemical structure of OMA. Overall, the results of this study suggests that the use of OMA as a crosslinker will allow the implantation of a hydrogel in tissue subject to an external mechanical loading with a desired protein-release profile. The OMA synthesized in this study will be, therefore, highly useful to independently control the mechanical properties and degradation rate of a wide array of hydrogels.
Publisher
WILEY-V C H VERLAG GMBH
ISSN
1616-301X

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.