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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery


Biodegradable Polymer Crosslinker: Independent Control of Stiffness, Toughness, and Hydrogel Degradation Rate

DC Field Value Language Cha, Chaenyung ko Kohmon, Richie E. ko Kong, Hyunjoon ko 2014-10-29T00:20:33Z - 2014-10-27 ko 2009-10 -
dc.identifier.citation ADVANCED FUNCTIONAL MATERIALS, v.19, no.19, pp.3056 - 3062 ko
dc.identifier.issn 1616-301X ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Hydrogels are being increasingly studied for use in various biomedical applications including drug delivery and tissue engineering. The successful use of a hydrogel in these applications greatly relies on a refined control of the mechanical properties including stiffness, toughness, and the degradation rate. However, it is still challenging to control the hydrogel properties in an independent manner due to the interdependency between hydrogel properties. Here it is hypothesized that a biodegradable polymeric crosslinker would allow for decoupling of the dependency between the properties of various hydrogel materials. This hypothesis is examined using oxidized methacrylic alginate (OMA). The OMA is synthesized by partially oxidizing alginate to generate hydrolytically labile units and conjugating methacrylic groups. It is used to crosslink poly(ethylene glycol) methacrylate and poly(N- hydroxymethyl acrylamide) to form three-dimensional hydrogel systems. OMA significantly improves rigidity and toughness of both hydrogels as compared with a small molecule crosslinker, and also controls the degradation rate of hydrogels depending on the oxidation degree, without altering their initial mechanical properties. The protein-release rate from a hydrogel and subsequent angiogenesis in vivo are thus regulated with the chemical structure of OMA. Overall, the results of this study suggests that the use of OMA as a crosslinker will allow the implantation of a hydrogel in tissue subject to an external mechanical loading with a desired protein-release profile. The OMA synthesized in this study will be, therefore, highly useful to independently control the mechanical properties and degradation rate of a wide array of hydrogels. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher WILEY-V C H VERLAG GMBH ko
dc.subject Acrylamides ko
dc.subject Angiogenesis ko
dc.subject Biomedical applications ko
dc.subject Chemical structure ko
dc.subject Crosslinker ko
dc.subject Crosslinks ko
dc.subject Degradation rate ko
dc.subject Hydrogel degradation ko
dc.subject Hydrogel system ko
dc.subject In-vivo ko
dc.subject Independent control ko
dc.subject Mechanical loading ko
dc.subject Oxidation degree ko
dc.subject Poly(ethylene glycol) methacrylate ko
dc.subject Release profiles ko
dc.subject Release rate ko
dc.subject Small molecules ko
dc.title Biodegradable Polymer Crosslinker: Independent Control of Stiffness, Toughness, and Hydrogel Degradation Rate ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-70349680606 ko
dc.identifier.wosid 000271132700004 ko
dc.type.rims ART ko
dc.description.wostc 32 *
dc.description.scopustc 33 * 2015-05-06 * 2014-10-27 *
dc.identifier.doi 10.1002/adfm.200900865 ko
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