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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery

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Fabrication of Microgel-in-Liposome Particles with Improved Water Retention

Cited 2 times inthomson ciCited 1 times inthomson ci
Title
Fabrication of Microgel-in-Liposome Particles with Improved Water Retention
Author
An, EunjungJeong, Choon BokCha, ChaenyungKim, Do HoonLee, HaekwangKong, HyunjoonKim, JunohKim, Jin Woong
Keywords
Cell structure; Continuous phase; Corneocytes; High concentration; Hydrogel structure; Lecithin-based microemulsion; Lipid layers; Lipid membranes; Long lasting; Microgel; Microgel particles; Multi core; Sodium hyaluronate; Stratum corneum; Water droplets; Water retention
Issue Date
2012-03
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.28, no.9, pp.4095 - 4101
Abstract
Corneocytes represents the main water reservoir of stratum corneum, and that ability intimately arises from their architecture and total composition. Here we describe a novel method for fabricating a microgel-in-liposome (M-i-L) structure consisting of a sodium hyaluronate microgel and a lipid membrane envelop in order to mimic corneocyte cell structures. The essence of our approach is to use a lecithin-based microemulsion with a very low interfacial tension between the water droplet and oil continuous phase. Using this emulsion enables us to stabilize a dispersion of microgel particles without phase separation or aggregation. The addition of excess water produced single-core or multicore microgel particles enveloped in a lipid layer. To demonstrate the applicability of this unique vesicle system, we encapsulated a high concentration of natural moisturizing factor (NMF) in the microgel core and investigated how the M-i-L structure affected the water retention in comparison with other control systems. We have observed that our M-i-L particles with the NMF in the core, which mimicked the corneocyte cell structure, showed an excellent ability to retain water in the system. This experimental result inspired us to investigate how corneocyte cells, which feature a lipid-enveloped hydrogel structure, provide such long-lasting hydration to the skin.
URI
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DOI
10.1021/la2046349
ISSN
0743-7463
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MSE_Journal Papers
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