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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery


Fabrication of Microgel-in-Liposome Particles with Improved Water Retention

DC Field Value Language An, Eunjung ko Jeong, Choon Bok ko Cha, Chaenyung ko Kim, Do Hoon ko Lee, Haekwang ko Kong, Hyunjoon ko Kim, Junoh ko Kim, Jin Woong ko 2014-10-29T00:20:13Z - 2014-10-27 ko 2012-03 -
dc.identifier.citation LANGMUIR, v.28, no.9, pp.4095 - 4101 ko
dc.identifier.issn 0743-7463 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Corneocytes represents the main water reservoir of stratum corneum, and that ability intimately arises from their architecture and total composition. Here we describe a novel method for fabricating a microgel-in-liposome (M-i-L) structure consisting of a sodium hyaluronate microgel and a lipid membrane envelop in order to mimic corneocyte cell structures. The essence of our approach is to use a lecithin-based microemulsion with a very low interfacial tension between the water droplet and oil continuous phase. Using this emulsion enables us to stabilize a dispersion of microgel particles without phase separation or aggregation. The addition of excess water produced single-core or multicore microgel particles enveloped in a lipid layer. To demonstrate the applicability of this unique vesicle system, we encapsulated a high concentration of natural moisturizing factor (NMF) in the microgel core and investigated how the M-i-L structure affected the water retention in comparison with other control systems. We have observed that our M-i-L particles with the NMF in the core, which mimicked the corneocyte cell structure, showed an excellent ability to retain water in the system. This experimental result inspired us to investigate how corneocyte cells, which feature a lipid-enveloped hydrogel structure, provide such long-lasting hydration to the skin. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher AMER CHEMICAL SOC ko
dc.subject Cell structure ko
dc.subject Continuous phase ko
dc.subject Corneocytes ko
dc.subject High concentration ko
dc.subject Hydrogel structure ko
dc.subject Lecithin-based microemulsion ko
dc.subject Lipid layers ko
dc.subject Lipid membranes ko
dc.subject Long lasting ko
dc.subject Microgel ko
dc.subject Microgel particles ko
dc.subject Multi core ko
dc.subject Sodium hyaluronate ko
dc.subject Stratum corneum ko
dc.subject Water droplets ko
dc.subject Water retention ko
dc.title Fabrication of Microgel-in-Liposome Particles with Improved Water Retention ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84863292711 ko
dc.identifier.wosid 000301038000009 ko
dc.type.rims ART ko
dc.description.wostc 2 *
dc.description.scopustc 1 * 2015-05-06 * 2014-10-27 *
dc.identifier.doi 10.1021/la2046349 ko
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