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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery

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Designing Biomaterials To Direct Stem Cell Fate

Cited 28 times inthomson ciCited 21 times inthomson ci
Title
Designing Biomaterials To Direct Stem Cell Fate
Author
Cha, ChaenyungLiechty, William B.Khademhosseini, AliPeppas, Nicholas A.
Keywords
Cell behaviors; Chemical factors; Extracellular; Extracellular matrices; Mechanical signals; Microenvironments; Regenerative medicine; Research efforts; Stem-cell niches
Issue Date
2012-11
Publisher
AMER CHEMICAL SOC
Citation
ACS NANO, v.6, no.11, pp.9353 - 9358
Abstract
As stem cells are a cornerstone of regenerative medicine, research efforts have been extensively focused on controlling their self-renewal and differentiation. It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, conventional cell culture approaches based purely on using soluble factors to direct stem cell fate have resulted In limited success. To account for the complexities of native stem-cell niches, biomaterials are actively investigated as artificial extracellular matrices in order to mimic the natural microenvironment. This Perspective highlights important areas related to the design of biomaterials to control stem cell behavior, such as cell-responsive ligands, mechanical., signals, and delivery of soluble factor's.
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DOI
10.1021/nn304773b
ISSN
1936-0851
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MSE_Journal Papers
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