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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery


Designing Biomaterials To Direct Stem Cell Fate

DC Field Value Language Cha, Chaenyung ko Liechty, William B. ko Khademhosseini, Ali ko Peppas, Nicholas A. ko 2014-10-29T00:20:10Z - 2014-10-27 ko 2012-11 -
dc.identifier.citation ACS NANO, v.6, no.11, pp.9353 - 9358 ko
dc.identifier.issn 1936-0851 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract As stem cells are a cornerstone of regenerative medicine, research efforts have been extensively focused on controlling their self-renewal and differentiation. It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, conventional cell culture approaches based purely on using soluble factors to direct stem cell fate have resulted In limited success. To account for the complexities of native stem-cell niches, biomaterials are actively investigated as artificial extracellular matrices in order to mimic the natural microenvironment. This Perspective highlights important areas related to the design of biomaterials to control stem cell behavior, such as cell-responsive ligands, mechanical., signals, and delivery of soluble factor's. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher AMER CHEMICAL SOC ko
dc.subject Cell behaviors ko
dc.subject Chemical factors ko
dc.subject Extracellular ko
dc.subject Extracellular matrices ko
dc.subject Mechanical signals ko
dc.subject Microenvironments ko
dc.subject Regenerative medicine ko
dc.subject Research efforts ko
dc.subject Stem-cell niches ko
dc.title Designing Biomaterials To Direct Stem Cell Fate ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84870399819 ko
dc.identifier.wosid 000311521700002 ko
dc.type.rims ART ko
dc.description.wostc 28 *
dc.description.scopustc 21 * 2015-05-06 * 2014-10-27 *
dc.identifier.doi 10.1021/nn304773b ko
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