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Ko, Myunggon
Cancer Epigenetics Lab.
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TET family proteins are dispensable for the structure and function of dopamine neurons in health and Parkinson’s disease

Lee, Byeong EunKim, Hye YunAn, JungeunKo, MyunggonKim, Jae-Ick
Issued Date
The 25th Annual Meeting of the Korean Society for Brain and Neural Sciences
DNA undergoes demethylation via the oxidation of 5-methylcytosine (5mC),
which is mediated by the Ten Eleven Translocation (TET) family of proteins.
Notably, 5hmC is highly enriched in the brain than in other tissues, the
level of which is dynamically regulated during development, aging, and
brain disorders. In addition, accumulating evidence has recently revealed
that 5-hmC and TETs play a significant role in synaptic functions, anxiety,
addiction, and cognition in several brain regions. Furthermore, TET enzymes
have turned out to be essential for diverse types of neurons in health and
brain disorders. In this study, by generating triple knockout (TKO) mice of
TET family proteins (TET1, 2, and 3) selectively in dopamine (DA) neurons,
we investigated the functional roles of TET proteins in the structure and
the function of DA neurons, which are pivotal for voluntary movement,
reward-related behaviors, and motivation. Here we unexpectedly show that
triple knockout (TKO) of all three TET proteins in dopamine (DA) neurons did
not lead to critical alterations of neuronal structure and function in normal
and pathological mouse brains. Thus, contrary to the previous reports, TET
family enzymes may be dispensable for the structure and function of neurons
in health and disease.
Korean Society for Brain and Neural Sciences


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